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Acquired Haemoglobin H Disease Associated with Myelodysplastic Syndrome
Author(s):
1. Syed Qamar Abbas: Department of Internal Medicine, Armed Forces Hospital,Sharourah, Kingdom of,Saudi Arabia
2. Nasiruddin: Department of Haematology, Armed Forces Hospital,Sharourah, Kingdom of,Saudi Arabia
3. Mohammed Misfer Al-Gethami: Department of Internal Medicine, Armed Forces Hospital,Sharourah, Kingdom of,Saudi Arabia
Abstract:
A 60-year-old male patient presented with jaundice. Initial investigations showed anemia, indirect hyperbilirubinemia, raised Lactic Dehydrogenase (LDH) and increased reticulocyte count suggestive of hemolysis. Considering hemolysis low MCV and basophilic stippling on peripheral film, hemoglobin electrophoresis was done that showed Haemoglobin H (15.5%) that in the absence of family history was thought to be acquired. After bone marrow examination, the final diagnosis was Myelodysplastic Syndrome (MDS), Refractory anemia with excess of blast (RAEB) associated with acquired Haemoglobin H (Hb H) disease.
Page(s): 784-786
DOI: DOI not available
Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 18, Issue: 12, Year: 2008
Keywords:
Myelodysplastic syndrome Hemolytic anemia Acquired Hemoglobin H
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