Engineering of tenofovir nanoparticle and stability assessment using isothermal approaches | [Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23 • 2023]

Author(s):

1. Nousheen Ali: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan

2. Sabahat Abdullah: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan

3. Zeeshan Mirza: Umm Al Qura University,Makkah, KSA

4. Asia Naz: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan

Abstract:

Tenofovir is effectively used for the treatment of HIV and HBV antiviral infections but it is prone to hydrolytic degradation in an aqueous medium which may affect its activity. Therefore in this study three different metallic nanoparticles of drug were fabricated using copper, zinc oxide and nickel chloride to improve physicochemical properties. These nanoparticles were characterized by UVS, FTIR, AFM and TGA-DSC. Thermal stability of tenofovir metallic nanoparticles was assessed by TGA and Horowitz – Metzger method was used to calculate decomposition kinetics of the drug and its metallic NPs. It was evident from the results that the tenofovir loaded nanoparticles were proved to be more stable then the drug itself. Considering the improved kinetic outcomes tenofovir loaded nano-delivery system may serve as a promising antiretroviral therapeutic agent upon further investigation.

Page(s): 57-57

DOI: DOI not available

Published: Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023

Keywords:

Nanoparticles , antiretroviral , HIV , Tenofovir , Horowitz Metzger

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