Age-related changes in RBC indices: a comparative cross- sectional study | [Journal of Postgraduate Medical Institute • 2024]

Author(s):

1. Umara Yousuf: Department of Physiology, Gujranwala Medical College,Gujranwala -,Pakistan

2. Sana Akhlaq: Department of Physiology, Gujranwala Medical College,Gujranwala -,Pakistan

3. Naima Shakeel: Department of Physiology, Gujranwala Medical College,Gujranwala -,Pakistan; Department of Physiology, AMC/PGMI,Lahore -,Pakistan

4. Sobia Niaz: Department of Physiology, Gujranwala Medical College,Gujranwala -,Pakistan

5. Javeria Latif: Physiology Department, CMH institute of medical Sciences,Bahawalpur -,Pakistan

6. Shazia Irfan: Physiology Department, FMH College of Medicine & Dentistry, Pakistan.

Abstract:

Objective: The primary objective of this comparative cross-sectional study is to elucidate age-related variations in peripheral blood parameters among a cohort of healthy males. Specifically, the study aims to investigate shifts in key hematological indices, with a particular emphasis on hemoglobin levels, across diferent age strata in males. Methodology: Data from 88 participants aged 18 to 92 years, all devoid of any known hematological disorders, were included in this study. Key peripheral blood parameters, including hemoglobin, red blood cell count, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration, were assess edvia a complete blood count test by Boule Medonic AB, Merck, Sweden counter. Participants were categorized into four age groups: I (aged 18 to 37 years),II (38 to 57 years), III (58 to 77 years), and IV (78 years and older). Results: A highly significant diference (p=<0.05) was noticed be tween hemoglobin, hematocrit, and mean corpuscular hemoglobin concentration among the four groups compared to a one-way ANOVA test. A negative correlation was observed between age and hemoglobin levels (r = -.575, p < .001), along with negative correlations between age and red blood cell count (r = -.439, p < .001) and hematocrit (r = -.445, p < .001).Conclusion: Red blood cells parameters varied with increasing age and differed between young males as compared to old age, indicating a decline in erythropoiesis in elderly males.Normocytic and normochromic anemia was observed in groups III and IV.

Page(s): 47-50

DOI: 10.54079/jpmi.38.3.3342

Published: Journal: Journal of Postgraduate Medical Institute, Volume: 38, Issue: 3, Year: 2024

Keywords:

Male , Anemia , Anemia , aging , Hemoglobin , Erythrocyte indices , Erythrocytes , Hematocrit , crosssectional studies , hematopoiesis , Agerelated changes

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