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A Review on Existing Tetracyclines Analogues and Their Pharmacologically Targeted SAR
Author(s):
1. Samreen Tanveer: Faculty of Pharmacy, University of Central Punjab Lahore,Pakistan
2. Athar Masood: Riphah Institute of Pharmaceutical Sciences, Riphah International University,Lahore,Pakistan
3. Kanwal Ashiq: Faculty of Pharmaceutical Sciences,Superior College 17-km Raiwind Road Lahore,Pakistan
4. Mehwish Qayyum: Faculty of Pharmaceutical Sciences,Superior College 17-km Raiwind Road Lahore,Pakistan
5. Mayyda Asif Bajwa: Faculty of Pharmaceutical Sciences,Superior College 17-km Raiwind Road Lahore,Pakistan
6. Asma Shah Rukh: University of Punjab, Pakistan
7. Afshan Arshad: Department of Allied Health Sciences,Superior College 17-km Raiwind Road Lahore,Pakistan
8. Raeesa Sattar: Department of Allied Health Sciences,Superior College 17-km Raiwind Road Lahore,Pakistan
Abstract:
Background: Tetracyclines belong to a class of broad spectrum antibiotics. Around the globe, they are prescribed to treat various gram negative and gram positive bacterial infections. Once in the cell, they reversibly bind to the receptors which are located on 30S subunit of bacterial ribosome. They act by averting the protein synthesis, in turn, halting the bacterial growth. Aim and Objectives: The aim of current review is to study tetracyclines, identifying potential activity against infections and highlighting the microbial resistance associated with various analogues. Material and Method: The data for this review is collected from various databases including Scopus, PubMed, Springer Link and Google Scholar. To ensure the credibility only indexed articles were used in current study. Result: The outcome of the study has suggested that tetracyclines and number of its analogues show selective bioactivity and strength to the biological targets. Through modification at certain positions, activity of drug is changed substantially. This not only affects therapeutic activity and safety profile but also has influence the bacterial resistance. Conclusion: As antibiotic resistance amongst bacteria is emerging tremendously, demanding more research. It is still needed to synthesize the novel analogues that would be helpful to cure infections caused by the resistant bacteria. Further these analogues can be tagged with radioisotopes that would be helpful for diagnosis and treatment of infectious diseases.
Page(s): 173-180
DOI: DOI not available
Published: Journal: RADS Journal of Pharmacy & Pharmaceutical Sciences, Volume: 8, Issue: 3, Year: 2020
Keywords:
Analogues , Antibacterial , Tetracycline , Structure activity
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