Synthetic N-Alkyl/aralkyl-4-methyl-N-,(naphthalen-1-yl)benzenesulfonamides as potent antibacterial agents. | [Pakistan Journal of Chemistry • 2015]

Author(s):

1. M. A. Abbasi: Department of Chemistry, Government College University, Lahore, Pakistan

2. S. Manzoor: Department of Chemistry, Government College University, Lahore, Pakistan

3. Aziz-ur-Rehman: Department of Chemistry, Government College University, Lahore, Pakistan

4. S. Z. Siddiqui: Department of Chemistry, Government College University, Lahore, Pakistan

5. I. Ahmad: Department of Pharmacy, The Islamia University of Bahawalpur, Pakistan

6. R. Malik: Department of Pharmacy, The Islamia University of Bahawalpur, Pakistan

7. M. Ashraf: Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

8. Qurat-ul-Ain: Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

9. S. A. A. Shah: Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia;Atta-ur-Rahman Institute for Natural Products Discovery, (AuRIns), Level 9, FF3, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia

Abstract:

The current research effort involved the reaction of napthalen-1-amine ,(1) with 4-methylbenzenesulfonyl chloride ,(2) under dynamic pH control at 9-10, maintained with 10% aqueous Na2CO3 to obtain 4-methyl-N-,(naphthalen-1-yl) benzenesulfonamide ,(3). The parent molecule 3 was further substituted at N-atom with alkyl/aralkyl halides ,(4a-f) in polar aprotic solvent; N,Ndimethylformamide, and lithium hydride which acts as a base, to achieve N-alkyl/aralkyl-4-methyl-N-,(naphthalen-1- yl)benzenesulfonamides ,(5a-f). All the synthesized compounds were structurally elucidated by IR, 1H-NMR and EIMS spectral techniques. All the derivatives were further screened for antibacterial and anti-enzymatic potential against various bacterial strains and enzymes, respectively, and were found to be potent antibacterial agents and moderate to weak enzyme inhibitors.

Page(s): 23-29

DOI: DOI not available

Published: Journal: Pakistan Journal of Chemistry, Volume: 5, Issue: 1, Year: 2015

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views