The effect of glucose variability on QTc duration and dispersion in patients with Type 2 Diabetes Mellitus | [Pakistan Journal of Medical Sciences • 2017]

Author(s):

1. Yasar Sertbas: Department of Cardiology, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey.

2. Ali Ozdemir: Department of Internal Medicine,Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey

3. Meltem Sertbas: Department of Cardiology, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey.

4. Akin Dayan: Department of Family Medicine,Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey.

5. Seda Sancak: Department of Cardiology, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey.

6. Cihangir Uyan: Department of Cardiology, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey.

Abstract:

Objective: Glycemic variability (GV) is a new term with the episodes of hyper and hypoglycemia in diabetic patients. Both prolonged QT interval and QTd are potential risk factors for malignant ventricular arrhythmias affecting the mortality of different groups of patients including diabetes mellitus. In this study, we aimed to evaluate if the glucose variability increasing the QTc interval and QTc dispersion in type 2 diabetes mellitus. Methods: We included 275 consecutive patients with type 2 diabetes. We quantified the GV with standard deviation (SD) and coefficient of variation (CV) from 7 point glucose measures. We investigated the relationship of GV parameters with QT parameters. Results: The prevalence of prolonged QTc duration was 21%, no patients have prolonged QTc dispersion (> 80 ms). SD of the patients with prolonged QTc duration was significantly higher than the others (45.14 ±24.45 vs. 37.78 ±9.03 p<0.05). There was also a significant relationship between SD and QTc dispersion (r: 0.164; p: 0.007). There were no relationship between the QT parameters and microvascular diabetic complications. SD and HbA1c levels were significantly higher on the patients having peripheral neuropathy (p<0.005). Conclusion: The result of this study demonstratess that increased glycemic variability is associated with prolonged QTc duration and QTc dispersion. It is important to focus on targeting optimal glycemic control with GV as an additional goal point along with the traditional following parameters such as fastingpostprandial blood glucose and HbA1c.

Page(s): 22-26

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 33, Issue: 1, Year: 2017

Keywords:

Glucose variability , QTc dispersion , QT duration

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