Abstract:
Breast Cancer (BC) is one of the most prevailing disease in women all over the world. Different 2D in vitro and in vivo models have been employed to investigate the BC. To investigate the tumor physiology, different 2D in vitro models have been used for culturing of tumor cell lines but 2D models failed to mimic microenvironment of tumors. To overcome the limitations of 2D models and to figure out the cancer initiation and progression mechanism, development of novel 3D models has gained valuable attention. 3D models have made it possible to investigate the insight biological alterations of breast cancerous cells. They enabled a better understanding of hemostasis, cell to cell & cell to ECM interactions, differentiation of cells as well as tissue organization, they provide precise environment for research as compared to complex in vivo host cell environment. In this review, different three- Dimensional models has been precisely elaborated for well- defined investigation of BC research, includes Multicellular Tumor Spheroids (MCTS), three-Dimensional (3D) bioprinting, Organoid Models, Microfluidic technologies, Organ on chip model, 3D hydrogel model and in silico approaches for BC, challenges and future of 3D models.
Page(s):
170-170
DOI:
DOI not available
Published:
Journal: Abstract Book on Global Science Technology and Management Conference, Volume: 0, Issue: 0, Year: 2023
Keywords:
Breast cancer
,
Insilico approaches
,
ThreeDimensional
,
organ on chip
,
Multicellular Tumor Spheroids
,
Microfluidic Technologies