The hepatoprotective role of Silymarin in isoniazid induced liver damage of rabbits | [Journal of Pakistan Medical Association • 2015]

Author(s):

1. Sarwat Jahan: Department of Pharmacology and Therapeutics, BMSI, Jinnah Postgraduate MedicalCenter (JPMC), Karachi, Pakistan

2. Moosa Khan: Department of Pharmacology and Therapeutics, BMSI, Jinnah Postgraduate MedicalCenter (JPMC), Karachi, Pakistan

3. Sana Imran: Department of Pharmacology and Therapeutics, BMSI, Jinnah Postgraduate MedicalCenter (JPMC), Karachi, Pakistan

4. Mohammad Sair: Department of Pharmacology and Therapeutics, BMSI, Jinnah Postgraduate MedicalCenter (JPMC), Karachi, Pakistan

Abstract:

Objective: To evaluate the hepatoprotective role of Silymarin against isonicotinylhydrazine-induced hepatotoxicity in rabbit model. Methods: The experimental animal study was held at Jinnah Postgraduate Medical Centre, Karachi, from April to September 2013 and comprised rabbits weighing 1-1.5kgof either gender. The animals were divided randomly into equal groups: group I underwent liver function test without any drug; in group II effects of Silymarin (50mg/kg/day orally) was observed; in group III isoniazid (50mg/kg/dayorally) was administered; and in group IV combined effects of isoniazid and silymarin were observed. Liver function tests were performed at day0 and after the treatment at day19. SPSS 16 was used for statistical analysis. Results: The 28 rabbits in the study were divided in four groups of 7(25%) each. No mortality was recorded in any group. In group III, bilirubin level was increased and alanine transaminase was decreased significantly (p

Page(s): 620-622

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 65, Issue: 6, Year: 2015

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