Author(s):
1. Lubna Rasheed:
Department of Chemistry, University of Education,Attock Campus,Pakistan
Abstract:
Designing and synthesis of suitable turn-on fluorescence sensors for monitoring intercellular Cr3+ is limited due to fluorescent quenching of paramagnetic Cr3+ and lack of Cr3+ selective multichelating ligand functionalities. To overcome the limitations related with the earlier developed methods, a fluorescent pyrene-based probe have been synthesized that selectively differentiate Cr3+ from alkali, alkaline earth metals and most of transition metals including Fe3+ ratiometrically in aqueous media. Interaction of Cr3+ with probe bring pyrene moieties close enough to have better aligned p-p stacking, which enhanced the excimer peak many fold. While the interaction of all other metals bring a insignificant difference in stacking, resulted a slight change in fluorescence intensity. Exceptional selectivity of probe with Cr3+ has been confirmed by density functional theory (DFT) studies in addition to experimental results. Confocal fluorescence microscopic imaging of HeLa cells revealed that probe can be used to monitor Cr 3+ in live cells to map its subcellular monitoring.
Page(s):
0-0
DOI:
DOI not available
Published:
Journal: First International Conference on Revamped Scientific Outlook of 21st Century (Abstract Book), Volume: 0, Issue: 0, Year: 2022
Keywords:
sensors
,
Fluorescence
,
Selective Detection
,
Pyrene
References:
References are not available for this document.
Citations
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