Multifunctional zinc oxide nanocomposites therapy and cytotoxicity study | [Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23 • 2023]

Author(s):

1. Fareeha Goher: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan

2. Asia Naz: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan

3. Sehrish Batool: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Pakistan

4. Hamza Soharwardi: Department of Metallurgical Engineering, NED UET, Karachi, 2522, Pakistan

5. Shahid Abro: Department of Metallurgical Engineering, NED UET, Karachi, 2522, Pakistan

6. Muhammad Raza Shah: H.E.J Research Institute of Chemistry, ICCBS, University of Karachi, Pakistan

Abstract:

In recent years, the development of multifunctional nanocomposites has gained significant attention in the field of biomedical research. The multifunctional nature of this nanocomposite holds great promise for various drug delivery applications, particularly in the field of antibacterial therapy. Zinc oxide (ZnO) has emerged as a promising antibacterial agent in biomedical applications. The antibacterial effects of ZnO nanoparticles are attributed to their unique physicochemical properties, such as high surface area and reactive oxygen species (ROS) generation. The mechanism of action involves the penetration of ZnO nanoparticles into bacterial cells, leading to intracellular ROS production and disruption of vital cellular processes, ultimately resulting in bacterial death. This study is designed to engineer Zinc oxide decorated Dextran-Chitosan nanocomposites which was used as nanocarrier to deliver neomycinfor synergistic antibacterial action. These nanoparticles were characterized for UV, FTIR, DLS, XRD, Zeta potential, SEM and TGA-DSC. Further drug release profile and release kinetics was assessed using Higuchi model, Hixson model, and the Korsmeyer model. Antibacterial efficacy against various microorganisms and cytotoxicity of the nanocomposites was evaluated on mouse fibroblast

Page(s): 47-47

DOI: DOI not available

Published: Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023

Keywords:

cytotoxicity , Antibacterial activity , korsmeyer model , Multifunctional nanocomposites , neomycin , zinc oxide

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views