Abstract:
Arsenic is one of those heavy metals that is found in contaminated water and soils in the form of organic and inorganic components. Inorganic form is more toxic, causes nervous dysfunction, neurological disturbances, cardiovascular problems, nephrotoxicity and hepatotoxicity. NAC (n-acetyl-L-cysteine) is a powerful antioxidant which has been used to cure various diseases and toxicity. The current study was conducted to examine the protective effect of nacetyl-L-cysteine against sodium arsenite (NaAsO2) induced tissue toxicity in albino mice. The experiment was conducted for 28 days and the mice were divided into eight groups. The first group was control received saline, second group received arsenic only, 3rd, 4th and 5th received NAC only while 6th, 7th and 8thwere the treatment groups. Arsenic treated groups showed significant increase in AST, ALP, ALT, creatinine, cholesterol, triglyceride, stress markers (ROS and TBARS) and Total protein while significant decrease occurred in the antioxidant enzyme such CAT, SOD, POD and GSH in kidney, liver and brain tissue as compared to control group. Arsenic treated groups also showed alterations in normal morphological architecture of kidney, liver and brain and non-significant decrease in the organ mass index was also observed in arsenic treated group. The result was found that high dose of NAC-150 significantly reduced alterations in oxidative stress and serum toxicity markers and restored the morphological alterations. It is concluded that NAC at a dose of 150 mg/kg is beneficial to treat arsenic induced toxicity in albino mice.
Page(s):
0-0
DOI:
DOI not available
Published:
Journal: First International Conference on Revamped Scientific Outlook of 21st Century (Abstract Book), Volume: 0, Issue: 0, Year: 2022
Keywords:
Toxicity
,
mice
,
antioxidants
,
Sodium arsenite
,
N acetyl cysteine