Abstract:
Objective: To compare the effects of antiviral therapy such as sofosbuvir and daclatasvir in HCV patients who were diagnosed by HCV-RNA PCR without Diabetes Mellitus. Methodology: In this cross-sectional analysis total of 100 Hepatitis c infected patients selected, Sofosbuvir plus Daclatasvir treatment was given for 03 months period. Different parameters were recorded such as Total Bilirubin, Direct Bilirubin, Indirect Bilirubin, Hb levels, Serum ALT levels, and Serum ALP level. The statistical relation of the mentioned variables was analyzed through SPSS version 15. Results: Out of a total of 100 patients, 47% (47) were males, 53% (53) were females, 44% (44) patients had a history of prior interferon therapy, 23% (23) patients were having low hemoglobin levels before starting treatment. Both groups completed oral antiviral treatment for 12 weeks and resulting data showed the equality of treatment on group B and group A as no decrease in hemoglobin (p=0.799), ALT normalization (p=1.000), and no rise in serum bilirubin (p=0.817) during 1st month of treatment was noted in both groups while the SVR noted of both groups also showed no significant difference to each other i.e. 92% & 94% (p=0.696). Conclusion: This study concluded that Sofosbuvir/ Daclatasvir tablets oral course of antiviral therapy against hepatitis C infected patients for 12 weeks showed excellent results, beneficial for the patients suffering from diabetes mellitus along with hepatitis C infection as compared with antiviral therapy for hepatitis C infected patients without diabetes
Page(s):
417-422
DOI:
DOI not available
Published:
Journal: Journal of Rawalpindi Medical College, Volume: 24, Issue: 4, Year: 2020
Keywords:
Deviated nasal septum
,
nasal septum corrective surgery
,
septoplasty
,
submucous resection