Abstract:
Schiff bases carrying two folded nitrogen known as the azomethine group have been reported against several pharmacological activities such as antifungal, antibacterial, and anticancer activities [1]. Furthermore, research work has been revolutionized toward nanotechnology as a nano drug delivery system, increasing the bioavailability of hydrophobic drugs, protecting the drug from the external environment, as well as controlling and sustaining the release of drugs from the mesh network of natural polymers [2]. Three synthetic Schiff bases and their polymeric nanoparticles were synthesized by the nanoprecipitation technique. Natural polymers were used to encapsulate the drug. The successful synthesis of Schiff Base was confirmed by Mass spectroscopy, FTIR, UV, and 1H-NMR and nanoparticles were confirmed by SEM, FTIR, and drug release study. These Schiff bases and their nanoparticles were further investigated by the disc diffusion method and significant compounds were further evaluated by minimum inhibitory concentration against the marketed drug fluconazole. The selected strains were Candida tropicalis, Candida albicans, Candida krusei, Saccharomyces cerevisae, Aspergillus flavus, and Aspergillus niger. Amongthese strains, only two strains were not resistant: Candida tropicalis and Candida krusei. Other nanoparticles showed moderate to significant activities against the remaining strains except Aspergillus flavus. However, against Candida tropicalis the HPMC polymer named, HHN3 (16.1±0.11) showed more significant activity as compared to the standard drug Fluconazole (12.33±1.15). it could be said that increased resistance to azoles, particularly fluconazole, as a result of irrational antifungal medication. One of Asia's emerging virulent species is C. tropicalis. It is the most common yeast causing systemic and superficial infections. According to the study, C. tropicalis is responsible for bloodstream and urinary tract infections in hospital patients and patients admitted to intensive care units (ICU), particularly in patients who use catheters frequently, taking broad-spectrum antibiotics, and cancer patients. Moreover, according to the drug release study, HHN3 showed sustained release 78% up to 8th hours. HPMC is a natural, biodegradable, non-toxic polymer.
Page(s):
160-160
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords:
HPMC
,
Schiff bases
,
Polymeric nanoparticles
,
Antifungal resistance