Synthesis, spectral characterization and antimicrobial studies of novel series of allylidene based multifaceted chalcones analogues | [Pakistan Journal of Pharmaceutical Sciences • 2020]

Author(s):

1. Misbah Irshad: Department of Chemistry, Division of Science and Technology, University of Education,Lahore,Pakistan

2. Qamar Ali: Department of Chemistry, Division of Science and Technology, University of Education,Lahore,Pakistan

3. Muhammad Athar Abbasi: Department of Chemistry, Government College University,Lahore,Pakistan

4. Fozia Iram: Department of Chemistry, Lahore College for Women University,Lahore,Pakistan

5. Mubshara Saadia: Department of Chemistry, University of Sargodha,Sargodha,Pakistan

6. Muhammad Hamza Ishfaq: Department of Chemistry, Division of Science and Technology, University of Education,Lahore,Pakistan

Abstract:

Following the Claisen Schmidt condensation a series of chalcone, their allylidene derivatives and metallic complexes were produced and subsequently screened for antibacterial assay. The precursors were simple acetophenone and different substituted aryl benzaldehydes; which were made to react in basic ethanolic conditions. The structure of synthesized targets was established by IR, 1H-NMR and EIMS data. The antibacterial statistics showed that most of the bacterial strains particularly S. typhi and E. coli were potently inhibited by majority of the compounds like 3c, 5c, 7a & 7c. This structure activity relationship studies showed that these molecules possessed p-methoxy substituents in their framework and found active in rupturing the cell wall. These molecules might serve as potential drug candidates for future drug discovery and design. The presented manuscript highlights the pharmacological diversity of chalcones holding allylidene moiety and Zn+2 complexes.

Page(s): 987-995

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 33, Issue: 3, Year: 2020

Keywords:

1HNMR , allylidene , EIMS , chalcones , metallation

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views