The Effect of Magnesium Sulfate Infusion on Postoperative Opioid Consumption in Abdominal Hysterectomy: A Randomised, Double-Blind Trial | [Journal of the College of Physicians and Surgeons Pakistan • 2025]

Author(s):

1. Ilke Tamdogan: Department of Anaesthesiology and Reanimation, Faculty of Medicine, Giresun University,Giresun,Turkiye

2. Dilek Yeniay: Department of Anaesthesiology and Reanimation, Giresun Gynaecology and Children's Diseases Training and Research Hospital,Giresun,Turkiye

3. Esra Turunc: Department of Anaesthesiology and Reanimation, Faculty of Medicine, Ondokuz Mayis University,Samsun,Turkiye

4. Fatma Alkan Bayburt: Department of Anaesthesiology and Reanimation, Faculty of Medicine, Giresun University,Giresun,Turkiye

5. Sadettin Oguzhan Tutar: Department of Gynaecology, Giresun Gynaecology and Children's Diseases Training and Research Hospital,Giresun,Turkiye

Abstract:

To assess the impact of magnesium sulfate infusion on total opioid consumption following abdominal hysterectomy in a clinical setting. Study Design: Controlled, randomised, prospective, and double-blind trial. Place and Duration of the Study:Department of Gynaecology, Giresun Gynaecology and Children's Diseases Training and Research Hospital, Giresun, Turkiye, from November 2023 to April 2024. Methodology: A total of 48 participants were randomly assigned to two groups: Group M (magnesium sulfate infusion) and Group N (placebo). Participants in Group M were administered a bolus 20 mg/kg MgSO4 in 100 mL of saline over 15 minutes prior to induction, followed by 20 mg/kg/h until skin closure. Participants in Group N received an equivalent volume of saline. The primary outcome was total opioid consumption within the rst 24 hours, while secondary outcomes included pain scores, remifentanil use, haemodynamic parameters, and adverse e ects. Results: Postoperative opioid consumption during the rst 24 hours was signi cantly lower in Group M (35.6 ± 15.2 mg) compared to Group N (44.9 ± 14.1 mg), with a p-value of 0.032. Pain scores were also signi cantly lower in Group M at 24 hours (p = 0.008) at rest, at 4 hours (p = 0.022), and 6 hours (p = 0.041) during movement. No signi cant di erences were observed in remifentanil consumption, haemodynamic parameters, sedation levels, or nausea between the two groups. Conclusion: The intraoperative administration of magnesium sulphate signi cantly reduced opioid consumption and pain scores following abdominal hysterectomy. These ndings support its use within multimodal analgesia strategies.

Page(s): 681-687

DOI: 10.29271/jcpsp.2025.06.681

Published: Journal: Journal of the College of Physicians and Surgeons Pakistan, Volume: 35, Issue: 06, Year: 2025

Keywords:

Hysterectomy , Analgesia , Postoperative pain , Magnesium Sulfate , patientcontrolled analgesia , Gynaecologic Anaesthesia

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