Abstract:
The escalating global crisis of Antimicrobial Resistance (AMR) and Multidrug Resistance (MDR) necessitates the urgent development of innovative, ecofriendly, and sustainable therapeutic strategies. With conventional antibiotic pipelines in decline, alternative approaches are critically needed. This study converges three cutting edge domains, green nanotechnology, traditional medicinal knowledge, and advanced drug delivery biotechnology to propose ac limate-resilient solution to AMR. We report the facile biosynthesis of carbon dots (CDs) and metallic nanoparticles (silver, zinc oxide) using phytochemical rich extracts of medicinal plants indigenous to the Hindu Kush ranges of Pakistan and Traditional Chinese Medicines (TCMs). These plants were selected based on their ethno pharmacological use against infectious diseases. The green synthesis process aligns with sustainability principles by minimizing toxic byproducts and reducing the carbon footprint compared to conventional chemical synthesis. The nanomaterial’s were extensively characterized (UV-Vis, FTIR,XRD, TEM, and DLS), confirming Nano scale dimensions, stable morphology, and bioactive phyto constituent capping. These nanoparticles demonstrated potent antimicrobial activity against MDR clinical isolates, including MRSA,ESBL-producing E. coli, and Klebsiella pneumoniae, alongside antifungal activity. A novel aspect of this research is the functionalization of CDs as smart nano carriers, enhancing the bioavailability and targeted delivery of active phytochemicals, thereby merging traditional medicine with modern biotechnology. Remarkably, synergistic effects were observed when green synthesized nanomaterial’s were combined with plant extracts, yielding significantly lower Minimum Inhibitory Concentrations (MICs) than either component alone. This not only improved efficacy but also reduced dosage requirements, minimizing toxicity and delaying resistance emergence. Overall, this work underscores the transformative potential of integrating green biotechnology with indigenous ethno pharmacology to develop effective, sustainable, and climate-resilient Nano therapeutics, offering a promising frontier in the global fight against AMR.
Page(s):
53-53
DOI:
DOI not available
Published:
Journal: 1st International Conference on "Recent Advances in Green Biotechnology and Climate Resilience", September 15-16, 2025, Volume: 1, Issue: 1, Year: 2025
Keywords:
drug delivery
,
metallic nanoparticles
,
Green nanotechnology
,
Antimicrobial resistance
,
Traditional medicine
,
Carbon Dots
,
Climate resilience