Valporic acid: Is it safe to use in epileptic pediatric patient? | [Pakistan Journal of Medical Sciences • 2009]

Author(s):

1. Abdulbaki Karaoglu: Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Ankara, Turkey

2. Ahmet Emin Kurekci: Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Ankara, Turkey

3. Vedat Okutan: Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Ankara, Turkey

4. Sebahattin Vurucu: Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Ankara, Turkey

5. Ridvan Akin: Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Ankara, Turkey

6. Avni Atay: Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Ankara, Turkey

7. Tuncer Cayc: Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Ankara, Turkey

8. Erdal Gokcay: Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Ankara, Turkey

Abstract:

Objective: To evaluate the effects of a 3-month low dose valporic acid treatment (20 mg/kg/day) on liver function tests, hematologic parameters, serum lipids and lipoprotein (a) levels in children. Methodology: Twenty-one newly diagnosed epileptic pediatric patients, nine female and 12 male, aged between 18 months and 14 years old (mean age 6.3±4.3 years), were enrolled in this study. valporic acid treatment was started with a dose of 20 mg/kg/day. To evaluate the effects of valporic acid on liver function tests, hematologic parameters, and serum lipids and lipoprotein levels were measured in pre-treatment and post-treatment 3rd month and values in pre-treatment were compared with values in post-treatment 3rd month. Results: There were no statistically significant differences between pre-treatment and post-treatment 3rd month values regarding liver function tests, hematologic parameters, and serum lipids (p>0.05). But lipoprotein (a) levels in the post-treatment 3rd month (40.71±50.73 mg/dl) were significantly higher than the pre-treatment levels (25.86±36.54 mg/dl) (p

Page(s): 539-544

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 25, Issue: 4, Year: 2009

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