Vitamin D Status in Patients with Cardiometabolic Syndrome. | [Journal of Medical Science • 2015]

Author(s):

1. Robina Usman: Department of Physiology, Peshawar Medical College, Peshawar, Pakistan

2. Farzana Khan: Department of Physiology, Peshawar Medical College, Peshawar, Pakistan

3. Shamaila Wadud: Department of Biochemistry, Peshawar Medical College, Peshawar, Pakistan

4. Shafaq Zafar: Department of Pharmacology, Peshawar Medical College, Peshawar, Pakistan

5. Zain-ul-Abideen: Department of Physiology, Peshawar Medical College, Peshawar, Pakistan

Abstract:

Objective: To compare the vitamin D status in patients of cardiometabolic syndrome (CMS) with that of normal individuals in our local population of Khyber Pakhtunkhwa (KPK), Pakistan. Material and Methods: Fifty adult patients of CMS and fifty controls were selected in Endocrinology Unit, Hayatabad Medical Complex (HMC), Peshawar by convenient consecutive sampling. Duration of study was from January 2012 to April 2012. Age, sex, height, weight, waist circumference, B.P (blood pressure) were measured. Fasting blood sugar (FBS) and lipid profile were assessed by using venous blood. Vitamin D status (25-hydroxyvitamin D) of patients and controls was analyzed by ELISA (Enzyme Linked Immunosorbent Assay). Data was analyzed using independent t-test, chi-square test and Levene's test for equality of variance. P value was calculated by Fischer exact test. Results: 42% had low vitamin D levels in the cases whereas 4% of controls had hypovitaminosis D. The odds ratio (OR) was 0.139 with confidence interval of .037 - .530 and P value < 0.01 which showed that vitamin D was a protective factor for the development of CMS. Conclusion: It is concluded that in our local population, there is significant prevalence of vitamin D deficiency in pa tients suffering from CMS.

Page(s): 172-175

DOI: DOI not available

Published: Journal: Journal of Medical Science, Volume: 23, Issue: 3, Year: 2015

Keywords:

Keywords are not available for this article.

References:

[1] WangTJ,PencinaMJ,BoothSL,JacquesPF,IngelssonE,LanierK, 2008.Vitamin D deficiency and risk of cardiovascular disease,Circulation 503 -11

[2] RosenCJ,AdamsJS,BikleDD,BlackDM,DemayMB,MansonJE, 2012.The nonskeletal effects of vitamin D: an Endocrine Society scientific statement,Endocr Rev 33 456 -92

[3] AlbertiKG,ZimmetP,ShawJ, 2005.The metabolic syndrome - a new worldwide definition,Lancet 366 1059 -62

[4] ZafarU,QureshiHJ,KarimA, 2011.Insulin resistance and serum parameters of iron status in type 2 diabetics,Pak J Physiol 7 28 -31

[5] BodnarLM,CatovJM,SimhanHN,HolickMF,PowersRW,RobertsJM, 2007.Maternal vitamin D deficiency increases the risk of preeclampsia,J Clin Endocrinol Metab 92 3517 -22

[6] MakiKC,FulgoniVL,KeastDR,RainsTM,ParkKM,RubinMR, .Vitamin D intake and status are asso19., -

[7] RelatedDisorders, 2012.ciated with lower prevalence of metabolic syndrome in U.S. adults: National Health and Nutrition Examination Surveys 2003-2006, 10 363 -72

[8] 2012.,ISRN Endocrinol 69 803 -09

[9] LuL,YuZ,PanA,HuFB,FrancoOH, 2010.Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals,Diabetes Care 33 13 -18

[10] Dihydroxyvitamin D3 induces Ca2, 2009.-mediated apoptosis in adipocytes via activation of calpain and caspase-12,Biochem Biophys Res Commun 384 18 -21

[11] MoyFM,BulgibaA, 2011.High prevalence of vitamin D insufficiency and its association with obesity and metabolic syndrome among Malay adults in Kuala Lumpur, Malaysia, 27 735 -38

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