The effect of streptomycin and penicillin on trace metal ions level in biological system. | [Pakistan Journal of Biological Sciences • 2000]

Author(s):

1. Fouzia S. Rehmani: Institute of BioChemistry, University of Balochistan, Quetta, Pakistan

2. Hummara Noor: Institute of BioChemistry, University of Balochistan, Quetta, Pakistan

3. Ehsanullwadood Khawaja: Bolan Medical College, Quetta, Pakistan

Abstract:

The potentiometric data of streptomycin and penicillin with trace metal ions show that Fe(111) and Cu(II) ions form very stable complexes with these antibiotics at physiological pH therefore prolonged therapy caused anemia. Ca(11) and Mg(II). ions do not form stable complexes. Cr(III) ions competes with Fe(III) binding sites. Co(II) and Ni(II) ions form complexes at neutral pH. The results indicate that these antibiotics lower the minerals level in the biological system. So it should be taken with minerals.

Page(s): 354-355

DOI: DOI not available

Published: Journal: Pakistan Journal of Biological Sciences, Volume: 3, Issue: 2, Year: 2000

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