Abstract:
Gold nanoparticles are unique due to their biocompatibility, physical characteristics, and optical properties . Nanoparticles must interact with biological systems in a controlled manner for their use in biomedicine to be successful. Thus, a method to green chemistry that is both cost-effective and environmentally friendly is to stabilize nanoparticles using organic material. The Turkevich method was used to produce gold nanoparticles, with sodium citrate and sodium borohydride serving as reducing agents and ferulic acid serve as a capping and stabilizing agent (FA-TSC-AuNps and FANaBH4-AuNps). Atomic force microscopy (AFM), Fourier transform infrared (FTIR), and UV-Vis spectrophotometer were used to characterize these produced nanoparticles. The average particle sizes of the two systems, FA-TSC-AuNps and FA-NaBH4-AuNps, were determined to be 4.7±1 nm and 10±1 nm, respectively, according to the AFM measurements. It was also assessed how pH and temperature affected the stability of nanoparticles. These produced gold nanoparticles were evaluated as heterogeneous catalysts for use in biological and environmental applications. The antiscavenging/antioxidant potential of FA-TSC-AuNps and FA-NaBH4-AuNps was determined by using DPPH and ABTS cation decolorizing potential,. The findings were found to be DPPH = 86.8%, 61.5% and ABTS = 70.14%, 92.8%, respectively. The anti-urease potential of FA-TSC-AuNps and FA-NaBH4-AuNps, however, is also estimated to be 56.9% and 76.9%, respectively. Additionally, the catalytic activity for environmental applications was assessed, with the pollutant p-nitro phenol converting to p-amino phenol (an analgesic and antipyretic molecule) in the presence of produced gold nanoparticles in less than a second. Chemosensing activity of produced gold nanoparticles for metals (mercury (Hg), cadmium (Cd), lead (Pb), manganese (Mn), nickel (Ni), aluminum (Al), and iron) and drugs (Ciprofloxacin, Cetrizine, Perindopril, and Sitagliptin) also evaluated. It has been determined that synthetic nanoparticles have significant biological impacts that could potentially be employed to change drug delivery methods and improve the efficacy of medications.
Page(s):
195-195
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023