The preparation and in vitro evaluation of antacid properties of saccharated magnesium hydroxide. | [Pakistan Journal of Scientific and Industrial Research • 1991]

Author(s):

1. I. H. Siddiqui: Pakistan Council of Scientific and Industrial Research (PCSIR), Karachi, Pakistan

2. R. Jafri: Pakistan Council of Scientific and Industrial Research (PCSIR), Karachi, Pakistan

3. M. Qadeeruddin: Pakistan Council of Scientific and Industrial Research (PCSIR), Karachi, Pakistan

4. S. A. H. Zaidi: Pakistan Council of Scientific and Industrial Research (PCSIR), Karachi, Pakistan

Abstract:

The preparation and in vitro antacid properties of polynuclear Mg- hydroxide chelate of sucrose (Sacch-Mg) have been studied. Its properties have been compared with those of a commercially available preparation containing Mg-hydroxide in suspension. 12.562 gm of Sacch-Mg contained 1 gm of elemental Mg. The neutralizing capacity of Sacch-Mg revealed that 1 gm of elemental Mg can neutralize 75.438 mEq. HCI. In respect of efficacy of the dose, duration of activity and maximum pH, it was observed that 0.0398 gm of elemental Mg can neutralize 50 ml of 0.1 NHCI to pH 1.80 in 15 mins, on successive addition of another 0.0398 gm of elemental Mg pH was raised to 3.7 and on addition of another 0.0398 gm elemental Mg pH was raised to 5.05. Buffering capacity showed that 2.2 ml of mEq. HCI was required to lower the pH of 0.0796 gm elemental Mg from 4 to 3.

Page(s): 479-482

DOI: DOI not available

Published: Journal: Pakistan Journal of Scientific and Industrial Research, Volume: 34, Issue: 12, Year: 1991

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