Trivalent Chromium Attenuated Corticosterone Secretion and Actions in Adrenocorticotropic Hormone-stimulated Rats. | [Pakistan Veterinary Journal • 2016]

Author(s):

1. Hsin-Hui King: Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing Unicersity, Taichunng, Taiwan, R.O.C..

2. Hsein-Chi Wang: Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing Unicersity, Taichunng, Taiwan, R.O.C.; Veterinary Medical Teaching Hospital, College of Veterinary Medicine, National Chung Hsing Unicersity, Taichunng, Taiwan, R.O.C.

3. Kuan-Sheng Chen: Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing Unicersity, Taichunng, Taiwan, R.O.C.; Veterinary Medical Teaching Hospital, College of Veterinary Medicine, National Chung Hsing Unicersity, Taichunng, Taiwan, R.O.C.

4. Wei-Ming Lee: Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing Unicersity, Taichunng, Taiwan, R.O.C.; Veterinary Medical Teaching Hospital, College of Veterinary Medicine, National Chung Hsing Unicersity, Taichunng, Taiwan, R.O.C.

Abstract:

Although mutual interplay between chromium and glucocorticoids exists, there is few data showing the effects of chromium on glucocorticoid secretion and actions. The aim of this study was to investigate the effects of chromium on glucocorticoid secretion and actions in adrenocorticotropic hormone (ACTH)-stimulated SpragueDawley rats. Rats were intraperitoneally administrated with ACTH (0.1 mg/kg BW/day) or saline and concomitantly supplemented with chromium (80 µg/kg BW/day) or placebo for 4 weeks. Chromium supplementation decreased the levels of corticosterone, AST, ALT, and ALP in ACTH-stimulated rats. Results of histological examination showed that chromium supplementation improved hypertrophic change in the zona fasciculata and the zona reticularis of adrenal glands and hepatic accumulation of lipid droplets in ACTH-stimulated rats. Chromium administration had an inhibitory effect on the corticosterone secretion by adrenal gland in ACTH-stimulated rats and attenuated the hepatic damage caused by hyperadrenocorticism.

Page(s): 41-44

DOI: DOI not available

Published: Journal: Pakistan Veterinary Journal, Volume: 36, Issue: 1, Year: 2016

Keywords:

Chromium Corticosterone Hyperadrenocorticism Rat

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views