Pakistan Science Abstracts
Article details & metrics
No Detail Found!!
Vitamin D levels and their relationship with the type of involvement in alopecia areata patients
Author(s):
1. Sabir Hasanbeyzade: Department of Dermatology and Venereology, Gulhane Millitary Medical Academy Hospital, Ankara, Turkey.
2. Mustafa Tunca: Department of Dermatology and Venereology, Gulhane Millitary Medical Academy Hospital, Ankara, Turkey.
Abstract:
Background Alopecia areata is an autoimmune dermatosis characterized by non-scarring loss of hair, especially of the beard, eyebrows and eyelashes. In this case-control study, we investigated the relationship between vitamin D levels and the disease and the type of involvement (patchy, diffuse, total and universal). Methods Forty one non-pregnant and over 18 years of age alopecia areata patients, who applied to the dermatology outpatient clinic of our hospital between 08.03.2016 and 31.05.2016 and who gave informed consent after being given verbal and written information about the study, were included in the study. The control group included 41 non-pregnant people over the age of 18 who applied to the outpatient clinic with complaints other than alopecia areata, matched with the patient group in terms of gender and age. Results There was no statistically significant difference in vitamin D levels between the control and patient groups, as well as between groups separated according to the type of involvement (p=0.06 and 0.72, respectively). There was no significant difference between the 2 groups with normal and low (<30ng/ml) vitamin D in terms of both disease and extent patterns (p=0.11 and 0.37, respectively).When all participants were divided into 3 groups in terms of vitamin D levels: normal, borderline low (20-29.9 ng/ml) and low (<20ng/ml), no statistically significant difference was found in terms of disease and extent patterns (p=0.17 and 0.33, respectively). Conclusion In our study, no statistically significant connection was found between the disease and the extent of involvement in terms of mean vitamin D levels and low vitamin D levels.
Page(s): 200-207
DOI: DOI not available
Published: Journal: Journal of Pakistan Association of Dermatologists, Volume: 34, Issue: 1, Year: 2024
Keywords:
Vitamin D , Alopecia areata , 25OHD3
References:
[1] Finner AM .2011 .Alopecia areata: Clinical presentation, diagnosis and unusual cases. Dermatol Ther, 24(3) : 348-54.
[2] De Berker DAR,Messenger AG,Sinclair RD,Burns T,Breathnach S,Cox N,Griffiths C . .Disorders of hair. Rook's Textbook of Dermatology. 7th ed. Oxford: Blackwell Science Ltd; 2004, : 3201-321.
[3] Rivitti EA .2005 .Alopecia areata: a revision and update. An Bras Dermatol, 80(1) : 57-68.
[4] Balevi Ş .2006 .. T Klin Dematol J Int Med Sci, 2(31) : 1-18.
[5] Wolff H ,Burgdorf WHC,Plewig G,Wolff HH,Landthaler M .2009 .Diseases of hair. Braun-Falco's Dermatology, : 1029-59.
[6] Arca E .2003 .Alopesi areatada etyopatogenez, klinik ve tanı. Dermatose, 2(3) : 83-9.
[7] McDonagh SJ,Tazi-Ahnini R .2002 .Epidemiology and genetics of alopecia areata. Clin Exp Dermatol, 27(5) : 405-9.
[8] Kalish RS,Gilhar A .2001 .The immunology of alopecia areata and potential application to novel therapies. Dermatol Ther, 14(4) : 322-8.
[9] Serarslan G,Savaş N,Yenin JZ .2012 .Is atopy and autoimmunity more prevalent in patients with alopecia areata? A comparative study. J Eur Acad Dermatol Venereol, 26(6) : 720-3.
[10] Green J,Sinclair RD .2000 .Genetics of alopecia areata. Australas J Dermatol, 41(4) : 213-8.
[11] Kılınç I,Alper S,Ceylan C .2002 .Alopesi areatalı olgularda hasta profili: Bir retrospektif çalışma. Ege Tıp Derg, 41(1) : 25-7.
[12] Wasserman D,Guzman-Sanchez DA,Scott D,McMicheal A .2007 .Alopecia areata. Int J Dermatol, 46 : 121-31.
[13] Thomas EA,Kadyan RS .2008 .Alopecia areata and autoimmunıty: a clinical study. Indian J Dermatol, 53(2) : 70-4.
[14] Aktaş E. .2005 .Alopesi areata tedavisindeki yenilikler. T Klin Dermatol, 1(48) : 103-8.
[15] Arca E .2003 .Alopesi areatada tedavi. Dermatose, 2(3) : 151-8.
[16] Gürkan A,Serdaroğlu S,Oğuz O .2010 .Ofiyazik modelli alopesi areata hastalarının tedavisinde skuarik asit dibütilester'in (Sadbe) etkinliği. , 1(1) : 9-13.
[17] Rajiv M,Singh NR .2010 .Bexarotene Gel: A New Topical Therapy for Alopecia Areata. Int J Trichol, 2(1) : 66-7.
[18] Gade V.K.V.,Mony A.,Munisamy M.,Chandrashekar L.,Rajappa M. .2018 .An investigation of vitamin D status in alopecia areata. Clin Exp Med, 18(4) : 577-584.
[19] Marahatta S,Agrawal S,Khan S. .2019 .Study on serum vitamin D in alopecia areata patients. J Nepal Health Res Counc, 17 : 21-5.
[20] Rehman F,Dogra N,Wani MA .2019 .Serum vitamin D levels and alopecia areata-a hospital based case--control study from North-India. Int J Trichol, 11 : 49-57.
[21] Siddappa H,Kumar YH,Vivekananda N. .2019 .Evaluation of association of vitamin D in alopecia areata: A case-control study of 100 patients in a tertiary rural hospital of Southern India. Indian Dermatol Online J, 10 : 45-9.
[22] Daroach M,Narang T,Saikia UN,Sachdeva N .2018 .Correlation of vitamin D and vitamin D receptor expression in patients with alopecia areata: a clinical paradigm. Int J Dermatol, 57 : 217-22.
[23] Erpolat S,Sarifakioglu E,Ayyildiz A .2017 .- hydroxyvitamin D status in patients with alopecia areata. Postepy Dermatol Alergol, 34 : 248-52.
[24] Yilmaz N,Serarslan G,Gokce C .2012 .Vitamin D concentrations are decreased in patients with alopecia areata. Vitamins & Trace Elements, 1 : 105-9.
[25] Kiliç S,Ersoy F,Sanal O,Türkbay D,Tezcan I. .1999 .Alopecia universalis in a patient with common variable immunodeficiency. Pediatr Dermatol, 16 : 305-7.
[26] Ahmed I,Masreen S,Bhatti R .2007 .Alopecia areata in children. J Coll Psysicians Surg Pak, 170 : 587-590.
[27] Oğrum A,Nermin B,Arzu KT,Seval K,Hatice ME .2015 .Alopesi areatalı hastalarda 25 hidroksi vitamin D₃ düzeyinin değerlendirilmesi. Türkderm, 49 : 50-3.
Citations
Citations are not available for this document.
0

Citations

0

Downloads

9

Views