Updates in the management of Guillain Barre Syndrome | [Anaesthesia, Pain and Intensive Care • 2018]

Author(s):

1. Novi Chandra Imelda: Neurology Department, Airlangga University- Dr. Soetomo General Hospital, Surabaya, East Java, (Indonesia)

2. Fadil Baktir: Neurology Department, Airlangga University- Dr. Soetomo General Hospital, Surabaya, East Java, (Indonesia)

3. Fidiana: Neurology Department, Airlangga University- Dr. Soetomo General Hospital, Surabaya, East Java, (Indonesia)

4. Hanik Badriyah Hidayati: Neurology Department, Airlangga University- Dr. Soetomo General Hospital, Surabaya, East Java, (Indonesia)

5. Mudjiani Basuki: Neurology Department, Airlangga University- Dr. Soetomo General Hospital, Surabaya, East Java, (Indonesia)

Abstract:

Guillain-Barre syndrome (GBS) was originally described by Landry in 1859 and Guillain, Barré and Strohl in 1916. Although GBS has a good prognosis (5% mortality rate), about 10% of patients experience serious disability one year after the start of neurological onset. Recent research of GBS shows that the process involves a number of subtypes with different immunological mechanism and a spectrum of clinical syndrome of acute inflammatory neuropathy. Antibodies against peripheral nerve gangliosides and their own complements are recognized as an important mechanism of nerve damage in GBS. Pharmacokinetics of intravenous immunoglobulin (IVIg) therapy and other related factors that influence prognosis has been researched. In order to investigate the possible role of complement inhibition in GBS management, new studies will be conducted. The management of GBS should be provided in appropriate hospital units, with specialist teams, intensive care and rehabilitation facilities as essential parts. This article aims to provide updated management of GBS.

Page(s): 54-57

DOI: DOI not available

Published: Journal: Anaesthesia, Pain and Intensive Care, Volume: 22, Issue: SI, Year: 2018

Keywords:

Management , GuillainBarre syndrome , Immunotherapy

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