Abstract:
Nanotechnology has turned the coin in favour of developing the novel drug delivery systems. The nanoparticles have been found very effective in the treatment of many challenging diseases including Cancer, AIDS and cardiovascular diseases etc. The scientists both from academia and R&D sections are struggling to develop the nanoparticles drug delivery systems to be administered into the body through different routes of administrations. However, the number of commercialised nanoproducts are still insignificant and a big room is there. A significant improvement in the advancement of nanocrystals, liposomes, exosomes and oral delivery of insulin has been reported in the last few years. In addition, there has also been witnessed a good progress in overcoming the biological barriers by the number of drug molecules using the novel Nano technological tools. The experimental scientists however, have not got success in underpinning most of the molecular level understanding of many mechanisms in the development of novel drug delivery systems. Therefore, the computational scientists add a significant value to develop the novel drug delivery system. For example, at nanoscale the behaviour of the drug particles is altered which results in different interaction with the biological components. In addition, the diffusion of the drug nanoparticles across the mucous membrane and their mechanistic understanding can also be addressed using coarse grained and atomistic modelling tools. The selection of suitable stabilisers for stability and phase transition of the nanoparticles is a key issue which can be investigated by MD simulation studies. The free energy of the bulk phase of drug particles are different compared to the nanoparticles. Thus, free energy is the key attribute to assess characteristics of the drug molecules.
Page(s):
88-88
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Life Sciences (ICLS-23) 11-12 May 22-23, Volume: 0, Issue: 0, Year: 2023