Abstract:
The dose dependent effect of cortisol in various doses (10-6, 10-7 , 10-8 and 10-9 mol/1 was studied with blood samples of human and rats in vitro and the parameters, accounted for, were evaluated from the data obtained. The parameters included, P 50 -value, Hill Coefficient (n) 2, 3-DPG concentration, Lactate concentration, Hct value, ATP concentration and Glucose concentration. The results showed a significant co-relation of the elevation of 2, 3-DPG and Lactic acid concentrations, exhibiting an induced effect of cortisol on red cell glycolysis. This effect was observed more pronounced in rats as compared to that of humans. In both series of experiments (rats and human), however, no significant change in the rest of the parameters could be noted. Conclusively, the effect of cortisol could be said to be representing simply an on/off reaction but no real dose dependent effect could actually be evaluated.
Page(s):
23-36
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Pharmacology, Volume: 4, Issue: 1, Year: 1987