The role of date palm pollen against adverse effects of Diabetic Neonatal Albino rats on infertility in their adult life | [Bioscience Research • 2022]

Author(s):

1. Reham A. Ghanem: Oral Biology Department, Faculty of oral and dental medicine, Delta University for Science and technology,Gamasa,Egypt

2. Amoura M. Abou-El-Naga: Zoology Department, Faculty of Science, Mansoura University,Mansoura,Egypt

3. Abd El-Fattah B.M. El-Beltagy: Zoology Department, Faculty of Science, Damanhour University,Damanhour,Egypt

4. Mervat A. Omran: Zoology Department, Faculty of Science, Mansoura University,Mansoura,Egypt

5. Yasmin M. Tag: Oral Biology Department, Faculty of oral and dental medicine, Delta University for Science and technology,Gamasa,Egypt

Abstract:

Diabetes mellitus (DM) is a metabolic disorder associated with a high level of blood glucose. In addition to disorders in carbohydrates metabolism, protein, and lipids which involved in the pathogenesis of female fertility due to the accumulation of free radicals. Date palm pollens are documented as antidiabetic and antioxidant as it used to enhance reproductive function and fertility in female humans and also in laboratory animals. The present work-study the role of DPP against the metabolic and structural changes in female rat ovaries and uteri of neonatally induced by streptozotocin. Twenty-four offsprings of female rats were used and separated into 4 groups (n=6). Group 1: control group, group 2: DPP group (1mg/kgbwt), group 3: the streptozotocin-induced group that subjected to a single intraperitoneal dose of streptozotocin (80 mg/Kgbw), and group 4: Streptozotocin plus DPP. Bodyweight, levels of female sex hormones, antioxidants, and lipid profiles were measured. In addition, histological and immunohistochemical examination of the ovarian and uterine specimens. Results displayed a significant depletion in the serum level of superoxide dismutase, catalase, and female sex hormone while a remarkable increase in serum lipid profile in the diabetic group. Furthermore, histopathological investigations showed the presence of atretic follicles, degenerated germinal epithelium, stromal hemorrhage, fragmented endometrial glands, and cellular hypertrophy in the ovaries and uterus in the diabetic group. Also, the ovarian section of the diabetic group displayed positive expression for NF?B and the uterine sections showed weak expression for B-cell lymphoma-2 if compared with the control. Conclusion: DPP has an ameliorative role in damaged ovaries and uteri by exhibiting hypoglycemic, hypolipidemic, antioxidant, anti-apoptotic adjustment, and female sex hormone modulation.

Page(s): 1332-1345

DOI: DOI not available

Published: Journal: Bioscience Research, Volume: 19, Issue: 3, Year: 2022

Keywords:

Diabetes , Diabetes , Immunohistochemistry , ovary , Diabetes , Rats , Flow cytometry , DPP , uterus

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