Abstract:
Objective: To compare the acute toxicities of two radiation treatment techniques, intensity modulated radiation therapy (IMRT), and 3-dimensional conformal radiation therapy (3D-CRT) in localised prostate adenocarcinoma. Study Design: Descriptive study. Place and Duration of the Study: Department of Oncology, Dr. Ziauddin Hospital, Karachi, Pakistan, from July 2016 to June 2022. Methodology: Patients with localised prostate adenocarcinoma who underwent treatment using two di erent advanced radiotherapy techniques i.e., IMRT and 3D-CRT were recruited during the study period. They were followed up for six months for acute gastrointestinal (GI) and genitourinary (GU) adverse events (acute toxicities) related to both treatment modalities according to Modi ed radiation therapy oncology group (RTOG) criteria. The acute toxicities were assessed at the n2d, 4th, and 6th week during treatment and at the 3rd and 6th month after treatment. Results: There were 78 patients, with 39 patients in each group. The mean age was 68 ± 10 years in the 3D-CRT and 68 ± 07 years in the IMRT group. Patients in the IMRT group exhibited markedly lower treatment-related acute GI and GU e ects at the end of 4th and 6th weeks for anorectal pain (p = 0.04) and (p = 0.01) and burning micturition (p = 0.003) and (p = 0.01), respectively. Furthermore, at 3 months anorectal pain (p = 0.02), loose stools (p = 0.005), and burning micturition (p = 0.01) were present and at 6 months anorectal pain was (p = 0.01) still present. Conclusion: Radiation therapy modalities 3D-CRT and IMRT both showed acceptable toxicity pro le in the management of localised prostate cancer, while IMRT group exhibited signi cantly lower treatment-related acute GI and GU e ects.
Page(s):
573-577
Published:
Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 34, Issue: 5, Year: 2024
Keywords:
3DCRT 3Dimensional Conformal Radiation Therapy
,
IMRT IntensityModulated Radiation Therapy
,
Radiation toxicity