Abstract:
OBJECTIVES: To investigate the relationship between serums resistin levels and ischaemic heart disease and severity of ischaemic heart disease. STUDY DESIGN: Cross sectional descriptive study. PLACE AND DURATION: This study was conducted in the Department of Physiology, Basic Medical Sciences Institute (BMSI), Jinnah Post Graduate Medical Center and the National Institute of Cardiovascular Diseases (NICVD), Karachi from 1st September 2008 to 30th April 2009. METHODOLOGY: After informed consent, ninety patients with confirmed diagnosis of coronary artery disease (CAD), diagnosed on the basis of history, physical examination, classical ECG changes and raised cardiac enzymes, were enrolled and divided into 3 equal groups: 30 patients each for acute myocardial infarction (AMI) unstable angina (UA) and stable angina (SA) and 30 healthy individuals were recruited as controls. Serum resistin levels were determind by ELISA (Resistin kit by SPI bio, Bertin Pharma, France Plate reader 800, manufactured by Biotech, USA). Complete blood count (CBC), Creatine kinase MB isoenzyme (CKMB) and Cardiac Troponin I (Trop I) were measured by standard laboratory methods. RESULTS: Serum resistin levels were found to be increased in CAD patients and to increase in parallel with increasing severity of CAD. Serum resistin levels were also positively correlated with CKMB, Trop I and white blood cell (WBC) count. CONCLUSION: The results suggest that human resistin may play an important role in the pathogenesis of atherosclerosis and ischaemic heart disease.
Page(s):
51-54
DOI:
DOI not available
Published:
Journal: Isra Medical Journal, Volume: 6, Issue: 2, Year: 2014