A stable hydrocortisone nanosuspension for improved dissolution: Preparation, characterization and in vitro evaluation | [Pakistan Journal of Pharmaceutical Sciences • 2017]

Author(s):

1. Hany SM Ali: Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taibah University, KSA; Pharmaceutics Department, Faculty of Pharmacy, Assiut University, Egypt

2. Shahzeb Khan: Department of Pharmacy, University of Malakand,Dir Lower, KPK,Pakistan

3. Peter York: Institute of Life Sciences, University of Bradford,BD7 1DP,UK

4. Syed Mukarram Shah: Department of Pharmacy, University of Sawabi KPK,Pakistan

5. Jahangir Khan: Department of Pharmacy, University of Malakand,Dir Lower, KPK,Pakistan

6. Zahid Hussain: Department of Pharmaceutics, Faculty of Pharmacy, University Teknologi Mara, Puncak Alam Campus,Malaysia

7. Barkat Ali Khan: Department of Pharmaceutics, Faculty of Pharmacy, Gomal University D.I Khan,KPK,Pakistan

Abstract:

Drug nanosuspensions have gained tremendous attraction as a platform in drug delivery. In the present work, a nanosuspension was prepared by a wet milling approach in order to increase saturation solubility and dissolution of the water insoluble drug, hydrocortisone. Size of the generated particeles was 290 nm ± 9 nm having a zeta potential of -1.9 mV ± 0.6 mV. Nanosized particles were found to have a rod shape with a narrow particle size distribution (PDI =0.17). Results of differential scanning calorimetry and X-ray diffraction analyses revealed minor modifications of crystallinity of hydrocortisone following the milling process. Solubility of hydrocortisone was enhanced by nanonization to 875µg/ml ±2.5, an almost 2.9-fold compared to the raw hydrocortisone. Moreover, the nanosuspension formulation substabtially enhanced the dissolution rate of hydrocortisone where >97% of the hydrocortisone was dissolved within 10 minutes opposed to 22.3% for the raw 50% for the raw hydrocortisone and the commercial tablet, respectively. The bioavailability study resulted in AUC 0-9h for HC nanosuspensions (31.50±2.50), which is significantly (p<0.05) higher compared to the AUC 0-9h (14.85±3.25) resulted for HC solution. The nanosuspension was physically stable at room temperature for 24 months.

Page(s): 1635-1643

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 30, Issue: 5, Year: 2017

Keywords:

dissolution , stability , Nanosuspension , Milling , solubility , Hydrocortisone

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