Antioxidative Role of Honey and L-Dopa against MPTP-induced Oxidative Stress in Adult Swiss Mice Model of Parkinson’s Disease | [Abstract Book on 9th Annual Neuroscience Conference (ANC-23) August 12-13, 2023 • 2023]

Author(s):

1. Sulaimon F.A: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin

2. Adeyemo E.A: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin

3. Yussuf R. A: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin

4. Emaye M.A: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin

5. Olaoye J.K: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin

6. Aina I.E: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin

7. Ashir F. A: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin

8. Jimoh H.B: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin

9. Ibiyeye R.Y: Department of Public Health Sciences (Anatomy Unit), Faculty of Pure and Applied Sciences, Kwara State University, Malete

10. Imam A.L: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin

11. Biliaminu S. A: Department of Chemical Pathology Faculty of Basic Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin

12. Shehu M: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin

13. Oyewole A.L: Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilori

14. Ajao M.S: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin

Abstract:

Oxidative stress is vital in the pathogenesis and progression of Parkinson’s disease (PD). 75% of dopaminergic (DA) neurons are already lost before the manifestation of the movement disorders. Moreover, one of the differential diagnoses of PD is its response to L-Dopa which does not prevent its progression. Hence, the need for neuroprotective therapy. Honey has been reported to be a radical scavenging gel and an enhancer of the antioxidant defence system. To investigate the antioxidative role of honey and L-Dopa against MPTP-induced oxidative stress.40 animals used for this study were divided into control and PD model groups of 20 animals each. Ten control animals received PBS, while the others received 1.5ml/kg body weight of honey and 80mg/ kg body weight of L-Dopa for 21 days. However, 10 of the PD model group were pretreated with HON and L-Dopa before PD induction. Behavioural studies were conducted two days after the induction, while the animals were euthanised seven days after. The result shows significantly (P=0.05) higher motor activities in the PD models pretreated with honey and L-Dopa. Furthermore, the pretreatment protected the midbrain against the gross neuronal damage and astrogliosis observed in the non-treated PD models. The expression of nuclear factor erythroid 2-related factor 2 (Nrf2) was also significantly upregulated (P=0.05) in the midbrain of the pretreated PD models. Pretreatment with honey and L-Dopa protected the DA neurons against oxidative stress via the mediation of the Nrf2 pathway.

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DOI: DOI not available

Published: Journal: Abstract Book on 9th Annual Neuroscience Conference (ANC-23) August 12-13, 2023 , Volume: 0, Issue: 0, Year: 2023

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