Vascular Inflammation Attributed by IL-6 and Thrombomodulin in Patients with Impaired Glucose Tolerance and Type 2 Diabetes Visiting a Local Hospital | [Pakistan Journal of Zoology • 2024]

Author(s):

1. Rehana Shahida: Department of Zoology, Lahore College for Women University, Lahore, Pakistan.

2. Shagufta Naz: Department of Zoology, Lahore College for Women University, Lahore, Pakistan.

3. Tasnim Farasat: Department of Zoology, Lahore College for Women University, Lahore, Pakistan.

4. Saima Sharif: Department of Zoology, Lahore College for Women University, Lahore, Pakistan.

5. Shah Jahan: Department of Immunology, University of Health Sciences, Lahore, Pakistan.

6. Farkhanda Manzoor: Department of Zoology, Lahore College for Women University, Lahore, Pakistan.

Abstract:

Diabetes mellitus type 2 (T2DM) is linked to a higher risk of atherosclerotic cardiovascular disease. The development and outcome of atherosclerosis are both influenced by vascular inflammation. The main purpose of this study is to find the impact of Interleukin-6 (IL-6) and thrombomodulin on vascular damage in the patients having impaired glucose tolerance (IGT) and to identify the relationship of IL-6 with insulin resistance. The patients visiting Amin Hayat Memorial Diabetic Center, Lahore from (January 2017 to October 2017) the subjects following WHO criteria of IGT and Diabetes were included. Demographic parameters as age, body mass index, waist/hip ratio, blood pressure, and socioeconomic status were recorded. Proatherogenic parameters like plasma glucose level, serum levels of insulin, thrombomodulin and IL-6 were measured by ELISA. The serum level of thrombomodulin was assessed as a measure of vascular damage. This study showed significantly elevated serum concentration of IL-6 and altered lipid profile in diabetes individual when compared with the control subjects. IL-6 and thrombomodulin was progressively higher in diabetic group. IL-6 correlated positively with thrombomodulin in the control group but an inverse association was seen in the IGT group and revealed that imbalance of the vascular damage initiated and that lead to damage of vascular endothelium in diabetes.

Page(s): 793-799

DOI: 10.17582/journal.pjz/20220820160858

Published: Journal: Pakistan Journal of Zoology, Volume: 56, Issue: 2, Year: 2024

Keywords:

inflammation , Vascular , Proatherogenic , Atherosclerotic

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