The biochemical and hematological changes in laparoscopic cholecystectomy | [Pakistan Journal of Life and Social Sciences • 2024]

Author(s):

1. Mohammed Abdul Hameed Younis: University of Sousse Tunisia /Faculty of Medicine Ibn el-Jazzar, Tunisia

2. Hussam Kareem: MBCHB, FICM, Ministry of Health, Imam Ali Hospital Tunisia

3. Wissem Hmida: University of Sousse Tunisia /Faculty of Medicine Ibn el-Jazzar, Tunisia

Abstract:

Hematological indicators, including neutrophils, leukocytes, neutrophil-lymphocyte ratio, platelet lymphocyte ratio, and mean platelet volume, have been observed to change following laparoscopic surgery. Blood parameter and liver enzyme level changes following laparoscopic cholecystectomy are the focus of this investigation. Participants in this study were those who had symptomatic cholelithiasis and had a laparoscopic cholecystectomy. Those patients who had other medical conditions, such as hepatitis and diabetes, and those who had to change from laparoscopic cholecystectomy to open cholecystectomy were not included in the study. The pre-operative and post-operative Hematological parameters and liver function tests were documented. The noted features included body mass index (BMI), gender, age, surgery indication, and duration, the pneumoperitoneum pressure, and duration of hospital stay. Various hematological parameters mean pre and postoperative values were compared using a paired sample t-test. HCT (hematocrite), hemoglobin (Hb), platelets, and alkaline phosphatase (ALP) levels all decreased after surgery. After the procedure, there was an increase in mean corpuscular volume (MCV), mean platelet volume (MPV), leukocytes, and alanine transaminase (ALT). The mean values of Hb, MCV, Hct, leukocytes, MPV, and ALT showed a statistically significant difference (p<0.05). Significant alterations in hematological parameters and liver enzymes occurred during LC.

Page(s): 2168-2174

DOI: 10.57239/PJLSS-2024-22.1.00159

Published: Journal: Pakistan Journal of Life and Social Sciences, Volume: 22, Issue: 1, Year: 2024

Keywords:

Laparoscopic Cholecystectomy Liver Function Tests Mean Platelet Volume Cholelithiasis

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