Clinical Utility of Serum Periostin as Biomarker of Diferential Diagnosis for different Phenotypes of Bronchial Asthma | [Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences • 2020]

Author(s):

1. Haji Muhammad Rashid: Department of Chemical Pathology, University of Health Sciences,Lahore,Pakistan

2. Mudassar Khan: Department of Medical Lab Technology, University of Haripur,Haripur,Pakistan

3. Jamal Khan: Department of Medical Lab Technology, University of Haripur,Haripur,Pakistan

4. Muhammad Aamer Sujjad: Department of Pathology, The Children Hospital & The Institute of Child Health,Multan,Pakistan

5. Hiza Hassan: Department of Medical Lab Technology, University of Haripur,Haripur,Pakistan

6. Hasanat Khan: Department of Medical Lab Technology, University of Haripur,Haripur,Pakistan

7. Mehreen Akhlaq Abbasi: Institute of Allied Health Sciences, University of Azad Jammu & Kashmir,Muzafarabad, Azad Kashmir,

Abstract:

Periostin is a protein produced from epithelial cells of the respiratory tract in response to the stimulation from IL-I3. Periostin levels in serum are associated with its production in airways. This study was conducted to evaluate the clinical utility of serum periostin levels in the diferential diagnosis of atopic and non-atopic asthma. This cross-sectional comparative study was carried out at Medsol Clinical Laboratory, Islamabad on 40 healthy individuals as control (Group A) and 40 asthmatic patients (Group B) from Jan-2020 to Aug-2020. Group B was comprised of 20 atopic asthmatic patients (Group BI) with positive skin prick test and 20 non-atopic asthmatic patients (Group BII) with negative skin prick test. Demographic data were obtained on proforma, lung function test and skin prick test was performed at pulmonologist clinic. EDTA and clotted blood samples were obtained from all participants to measure absolute eosinophil count (AEC) and periostin levels. Serum periostin levels were significantly higher in asthmatic patient Group B (396 ± 84) than healthy controls Group A (185 ± 40). In asthmatic groups, serum periostin levels were significantly higher in group BI (atopic asthmatic) than group B II (non-atopic asthma). There was a strong association between serum periostin and AEC (0.83), serum periostin, and FEV1 (-0.81) in atopic asthmatic patients. We concluded that serum periostin can be used for the diagnosis of bronchial asthma and a good purposed biomarker for diferential diagnosis of different phenotypes of asthma.

Page(s): 9-13

DOI: DOI not available

Published: Journal: Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, Volume: 57, Issue: 4, Year: 2020

Keywords:

asthma , Periostin , Phenotypes , T2 disease , Th2 Inflammation , Eosinophils , Atopy , NonT2 disease

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