A Comparison of Analgesic and Anti-Inflammatory Activities of Portulaca oleraceae Leaf and Seeds. | [RADS Journal of Pharmacy & Pharmaceutical Sciences • 2018]

Author(s):

1. Nudrat Fatima: Department of Pharmacognosy, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan

2. Shazia Syed: Department of Chemistry, University of Karachi, Karachi, Pakistan

3. Mansoor Ahmad: Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan

4. Noor Jahan: Department of Pharmacology, Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan

5. Mehjabeen: Department of Pharmacology, Federal Urdu University of Science and Technology, Karachi, Pakistan

Abstract:

Background: Portulaca oleraceae is a widely utilized herb as nutrition and medicine. It is an important fragment of Chinese and Ayurveda medicines since centuries. Whole plant and seeds of P. oleraceae has been reported for a number of medicinally important phytoconstituents. Objective: A lot of research work is carried out on the whole plant regarding pharmacological activities including analgesic and anti-inflammatory activities, but as far as seed part is concerned, a little work is carried out. So a comparative study was designed to investigate the pain relieving and edema reducing properties of leaf versus seeds of P. oleracea. Methods: Extract was prepared by classical reported method. Analgesic activity was conducted by two different methods i.e. Hot plate and Writhing tests, while anti-inflammatory activity was conducted using Formalin test. Dunnett's t-test was used to analyze the data. Results: The result indicated that seed extract inhibits inflammation to a greater extent than leaf extract. Regarding analgesic activity by both methods, leaf extract is proven to be more potent analgesic than seed extract in early phase while again seed extract is better analgesic in late phase. Conclusion: Comparative results show that Portulaca oleraceae seed extract possess persistent higher analgesic effect in high doses and significant antiinflammatory activity than leaf extract. So further work can be carried out in combination of leaf and seed extract to obtain continuous activity in both early and late phases of analgesia.

Page(s): 194-199

DOI: DOI not available

Published: Journal: RADS Journal of Pharmacy & Pharmaceutical Sciences, Volume: 6, Issue: 3, Year: 2018

Keywords:

Antiinflammatory , analgesic , seed extract , leaf extract , Portulaca oleraceae

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