The effects of alendronate treatment in the diagnosis and management of proximal femur osteoporosis: A real-life scenario | [Pakistan Journal of Pharmaceutical Sciences • 2021]

Author(s):

1. Muhammad Asadullah: Fazaia Ruth Pfau Medical College, PAF Base Faisal,Karachi,Pakistan

2. Sana Sarfaraz: Department of Pharmacology, Faculty of Pharmacy & Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan

3. Sana Tanzil: Fazaia Ruth Pfau Medical College, PAF Base Faisal,Karachi,Pakistan

4. Rahela Ikram: Faculty of Pharmacy, Salim Habib University,Karachi,Pakistan

5. Noor Kamil: Faculty of Pharmacy, Salim Habib University, Karachi, Pakistan

Abstract:

Currently the increased focus is being given to reforming osteoporosis regimens. Optimizing the evaluation of pharmacological intervention occurs once a medicine has been approved. There is literature available on the use of alendronate in bone loss. The current study focuses on the efficacy assessment of alendronate on proximal femur bone density loss. Current work was carried out to analyze the data of the BMD. The study comprised of females who had received at least six months of Alendronate (70mg/week) for proximal femur osteoporosis. SPSS version-22 was used for analysis and a comparative change was regarded therapeutically significant. The reliability of the research was ensured by reporting cover-up and withdrawals. Among all the study participants who received Alendronate therapy the median height of females in centimeters (cms) was 155 (IQR =16) and the median weight was 55.5 Kilograms (Kgs) (IQR =15). The mean age of the population was 50.59±14.714. The study found the median T-score before therapy was -2.9 (IQR=0.7) and the median T-score after therapy was -2.51(IQR=1). The estimated difference of mean rank was statistically significant for pre- and post-therapy T-score (p=0.008). Hence, the results of this study indicate an improvement in BMD as a result of therapy. Alendronate at 70 mg per week is effective in reducing hip osteoporosis.

Page(s): 1393-1396

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 34, Issue: 4, Year: 2021

Keywords:

Osteoporosis , Bone mineral density , Hip fractures , Alendronate

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