Abstract:
Objective: To investigate the appropriateness of Bentley and plasmic scores andADAMTS-13 activity to distinguish between primary thrombotic microangiopathies (TMA) syndromes and other thrombotic microangiopathies, as well as primary thrombotic microangiopathies (TTP, complement-related TMA, etc). Study Design: Descriptive study. Place and Duration of the Study: Department of Hematology, Faculty of Medicine, from February 2013 to February 2020. Methodology: Data of patients with non-immune hemolytic anaemia (MAHA) and thrombocytopenia who had ADAMTS-13 test, were analysed. Clinical and laboratory ndings, Bentley and plasmic scores, and ADAMTS activity levels were compared. Results: The patients were grouped as primary (n = 27) and secondary (n = 28) TMA, the age was median 38.0 (18-63) years in the primary TMA group and 49.5 (20-84) years in the secondary TMA group. Neurological ndings were less in the secondary TMA group (p = 0.008). Plasmic score, lactate dehydrogenase, and total and indirect bilirubin levels were high and D-dimer levels were low in the primary TMA group. In the primary TMA group, a greater number of patients with high plasmic scores were found, whereas all patients in the secondary TMA group had low risk according to Bentley score. Calcium levels were high and platelet levels were low in those with ADAMTS activity level <10%p( = 0.006). The evaluation of primary TMAs demonstrated signi cant di erences in platelet, urea, creatinine, and sodium values between the two groups. Conclusion: Laboratory data and clinical scores are valuable in di erentiating primary and other TMA.
Keywords:
Complement
,
Thrombotic thrombocytopenic purpura
,
thrombotic microangiopathy
,
Bentley score
,
Plasmic score
,
ADAMTS13