Abstract:
Multi-drug-resistant tuberculosis (MDR-TB) is a threat to global health. In 2018, TB related death was estimated to be more than 1.5 million cases worldwide. Conventional diagnostic method, which requires ulti-drug-resistant tuberculosis (MDR-TB) is a threat to global health. In 2018, TB related death was a long time to get a result, causes delays in new cases discoveries that lead to delayed therapy. Further, delayed and inadequate therapy causes an increase in the level of resistance to anti-TB drugs that may lead to death. Therefore, diagnostic tools, which can detect quickly and accurately, are highly needed. Early and timely detection is crucial for globally effective TB control, but this is not popular in developing countries, especially in Asia. Therefore, the objective of this review is to provide current information on the use of NGS as a rapid diagnostic tool for MDR-TB, especially in Asian populations, and to highlight the various MDR genes.
Page(s):
30-37
DOI:
DOI not available
Published:
Journal: Advancements in life sciences, Volume: 8, Issue: 1, Year: 2020
Keywords:
Tuberculosis
,
Mycobacterium tuberculosis
,
Rapid diagnosis
,
Next Generation sequencing
,
MultiDrug Resistance