The effects of germanium biotite supplement as a prophylactic agent against respiratory infection in calves. | [Pakistan Veterinary Journal • 2012]

Author(s):

1. Myunghwan Jung: Department of Infectious Diseases, College of Veterinary Medicine, KRF Zoonotic Disease Priority Research Institute and Brain, Korea

2. Jung Bock-Gie: College of Veterinary Medicine, Chonnam National University, 300 Yongbong-dong, Buk-gu, Gwangju 550-757, Korea

3. Seung Bin Cha: Department of Infectious Diseases, College of Veterinary Medicine, KRF Zoonotic Disease Priority Research Institute and Brain Korea

4. Shin Min-Kyoung: Department of Infectious Diseases, College of Veterinary Medicine, KRF Zoonotic Disease Priority Research Institute and Brain Korea

5. Lee Won-Jung: Department of Infectious Diseases, College of Veterinary Medicine, KRF Zoonotic Disease Priority Research Institute and Brain Korea

6. Seung Won Shin: Department of Infectious Diseases, College of Veterinary Medicine, KRF Zoonotic Disease Priority Research Institute and Brain Korea

7. Lee Jin-A: Program for Veterinary Science, Seoul National University, Seoul, 151-742, Korea

8. Jung Yeon-Kwon: Seobong BioBestech. Co, Ltd, Hyechon Building #401, 831 Yeoksam-dong, Kangnam-gu, Seoul, Korea

9. Lee Bong-Joo: Program for Veterinary Science, Seoul National University, Seoul, 151-742, Korea; College of Veterinary Medicine, Chonnam National University, 300 Yongbong-dong, Buk-gu, Gwangju 550-757, Korea

10. Han Sang Yoo: Department of Infectious Diseases, College of Veterinary Medicine, KRF Zoonotic Disease Priority Research Institute and Brain, Korea

Abstract:

Germanium biotite, a natural mineral, is comprised of mainly silicate. This mineral showed activities of increase in feed efficiency and non-specific immunostimulation in previous studies. The aims of the present study were to evaluate the prophylactic effects of germanium biotite against respiratory diseases in calves as a feed supplement and investigate the possibilities of the substitution of antibiotics with germanium biotite as feed additive. To achieve these purposes, bovine herpesvirus-1 (BHV-1) and Mannheimia haemolytica serotype A1 were experimentally inoculated into the calves. After challenge, germanium biotite showed a lower cumulative clinical score (CCS) than the control group. In accordance with these clinical results, enhanced clearance of BHV-1, a low infection rate of Mannheimia haemolytica serotype A1, tempered superficial lesions, and moderated histopathological signs were observed in the germanium biotite group, compared with the control group. The results of the present study indicated that germanium biotite had prophylactic effects against bovine respiratory disease and could be a candidate for a new alternative feed supplement in calves, through its effects as a non-specific immune stimulator.

Page(s): 319-324

DOI: DOI not available

Published: Journal: Pakistan Veterinary Journal, Volume: 32, Issue: 3, Year: 2012

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