Determination of triprolidine-HCl by spectrophotometric method in pure and pharmaceutical preparations using dichloronitrobenzene as a new chromogenic reagent. | [Proceedings of Pakistan Academy of Sciences • 2005]

Author(s):

1. Amina Mumtaz: Applied Chemistry Research Centre, PCSIR Laboratories Complex, Lahore-54600, Pakistan

2. Asrar A. Kazi: Applied Chemistry Research Centre, PCSIR Laboratories Complex, Lahore-54600, Pakistan

3. Tehseen Aman: Applied Chemistry Research Centre, PCSIR Laboratories Complex, Lahore-54600, Pakistan

4. M. Usman Sabri: Applied Chemistry Research Centre, PCSIR Laboratories Complex, Lahore-54600, Pakistan

5. Fauzia Noureen: Applied Chemistry Research Centre, PCSIR Laboratories Complex, Lahore-54600, Pakistan

Abstract:

In the present study it is demonstrated that H1- blockers such as triprolidine-HCl can be determined by a very simple, sensitive and accurate spectrophotometric procedure. The method consisted of interaction of triprolidine-HCl with dichloronitrobenzene in alkaline medium. Absorbance of resulting orange colour was measured at 440 nm.The reaction turned out to be selective for triprolidine -HCl with 0.005 mgml-1 as the visual limit of identification and provided a basis for a new spectrophotometric determination. The reaction obeyed Beer`s law from 0.05 mg to 0.15 mgml-1 for triprolidine-HCl and the relative standard deviation was 0.60 %. The quantitative assessment of other drugs was also studied.

Page(s): 253-259

DOI: DOI not available

Published: Journal: Proceedings of Pakistan Academy of Sciences, Volume: 42, Issue: 4, Year: 2005

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views