Synthesis and antibacterial activity study of N-substituted acetamide derivatives of 4-hydroxy-2-oxo-2H-chromene. | [Pakistan Journal of Chemistry • 2015]

Author(s):

1. Aziz-ur-Rehman: Department of Chemistry, Government College University, Lahore, Pakistan

2. S. Rasool: Department of Chemistry, Government College University, Lahore, Pakistan

3. M. A. Abbasi: Department of Chemistry, Government College University, Lahore, Pakistan

4. S. Z. Siddiqui: Department of Chemistry, Government College University, Lahore, Pakistan

5. A. Riaz: Department of Chemistry, Government College University, Lahore, Pakistan

6. A. Tahir: Department of Chemistry, Government College University, Lahore, Pakistan

7. H. M. A. Asif: Department of Chemistry, Government College University, Lahore, Pakistan

8. I. Ahmad: Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Abstract:

The heterocyclic coumarin derivatives are well known for their biological potential. The presented work demonstrates the evaluation of some N-substituted acetamoyl derivatives of 4-hydroxy-2-oxo-2H-chromene ,(4) against certain strains of gram bacteria. First, N-substituted-2-bromoacetamide, 3a-r, were synthesized by the reaction of aralkyl/aryl amines, 1a-r, with 2- bromoacetyl bromide ,(2) in an aqueous medium under definite pH control. In the second step, the resulted electrophiles, 3a-r, were made to react 4 in a polar aprotic solvent using a weak base as an activator to synthesize the final N-substituted-2-[,(2-oxo- 2H-chromen-4-yl)oxy]acetamide, 5a-r. The synthesis of compounds, 5a-r, was corroborated by TLC initially and spectral data of IR, 1H-NMR and EIMS finally. The MIC results of antibacterial activity rendered these molecules valuable inhibitors of all the bacterial strains taken into account.

Page(s): 49-56

DOI: DOI not available

Published: Journal: Pakistan Journal of Chemistry, Volume: 5, Issue: 2, Year: 2015

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