The synthesis of a series of N, N’ –[Bis-disubstituted aminomethyl] - S-arylidenebarbituric acids, and their antiinflammatory activity. | [Journal of Chemical Society of Pakistan • 1980]

Author(s):

1. S. M. M. Zaidi: Chemistry Department, Shia Degree College, Lucknow, India

2. R. K. Satsangi: Chemistry Department, Lucknow University, Ldcknow, India

3. S. S. Tiwari: Chemistry Department, Lucknow University, Ldcknow, India

Abstract:

5-arylidene barbituric acids were obtained by the Perkin condensat ion between a series of aromatic aldehydes and the active methylene group of barbituric acid. Through Mannich condevation of these barbituric acid derivatives with secondary amines and formaldehyde, twelve Mannich bases were prepared. Six of the final compounds were screened for their anti-inflammatory activity and toxicity. Three compounds were found to inhibit inflammation by 20%-32%.

Page(s): 97-99

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 2, Issue: 3, Year: 1980

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