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Tetramethylpyrazine Mitigates Toxicity and Liver Oxidative Stress in Tibial Dyschondroplasia Chickens.
Author(s):
1. Khalid Mehmood: College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China: College of Veterinary and Animal Sciences, Islamia University of Bahawalpur, Pakistan
2. Hui Zhang: College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China
3. Muhammad Kashif Iqbal: College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China
4. Mujeeb Ur Rehman: College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China
5. Kun Li: College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China
6. Shucheng Huang: College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China
7. Muhammad Shahzad: College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China
8. Fazul Nabi: College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China
9. Mujahid Iqba: College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China
10. Jiakui Li: College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China: College of Animals Husbandry and Veterinary Medicine, Tibet Agricultural and Animal Husbandry University, Linzhi, Tibet 860000, PR China
Abstract:
Tibial dyschondroplasia (TD) is a skeletal abnormality in fast growing bird, which causes down grading and serious poultry welfare issues in meat industry. TD is described as a non-viable and un-mineralized cartilage in the tibial growth plate of chickens which fails to become bone. The present study was designated to check the effect of Tetramethylpyrazine (TMP) on liver oxidative stress and toxicity in thiram induced tibial dyschondroplasia chickens. One hundred and eighty (1-day old) broiler chickens were equally divided into three groups including Control, Thiram induced (50mg/kg/d) and TMP treatment (30 mg/kg/d). All groups were raised under standard hygienic conditions and chickens were slaughtered to collect blood, liver and tibial bone samples on day 7, 10, 14 and 18 from each group. Thiram caused lameness, and significantly decreased ALP activity and increased ALT and AST contents in the serum of thiram group as compared to control group. The level of GSH-Px, T-AOC and SOD was significantly decreased (P<0.05), while the MDA value and size of growth plate (GP) was increased in TD afflicted chickens as compared to control group. However, the TMP administration increased the ALP contents, and decreased the AST and ALT contents significantly (P<0.05). Furthermore, it increased SOD, T-AOC and GSH-Px and decreased MDA contents significantly (P<0.05). TMP treatment to TD afflicted birds prevented lameness, while reinstated the size of growth plate, angiogenesis, and antioxidant imbalance. TMP may be effective to treat and control of TD along with minimizing the liver damages in TD chickens.
Page(s): 76-80
Published: Journal: Pakistan Veterinary Journal, Volume: 38, Issue: 1, Year: 2018
Keywords:
Keywords are not available for this article.
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