Author(s):
1. Farzana Yasmin:
Department of Biomedical Engineering, NED UET, Karachi, Pakistan
2. Samreen Feroz:
Department of Biomedical & Biological Sciences, AKUH, Karachi, Pakistan
3. Mustafain Ali:
Department of Biomedical Engineering, NED UET, Karachi, Pakistan
Abstract:
The main aim of this study is to identify the importance of brain derived neurotrophic factors effect on Alzheimer's disease (AD) with the help of anti-depressant drugs. Antidepressant drugs inhibit the amyloid beta deposition process by increasing the levels of BDNF in the blood. Brain-derived neurotrophic factor (BDNF) further ameliorates the intensity of mild to cognitive AD by inhibiting the glutamic pathways that increase the production of amyloid beta protein. The novelty of this research uproots from the fact that no protein docking has ever been performed to display the relationship that exists between BDNF and Alzheimer's disease (AD). The relationship between BDNF and AD has been highlighted with the help of protein docking of Aß peptide protein and a range of antidepressant drugs that directly affect Brain-derived neurotrophic factor in an Alzheimer's patient. The Literature review was done accounting the relationship between BDNF, Antidepressant drugs and Alzheimer's disease. Drug bank was used to extract antidepressant drugs, the protein structures of anti-depressant drugs and amyloid beta, were taken from RCSB and further evaluated with the help of Geno3D and CTD. PROCHECK was used to ensure the overall model quality Pyrx, PyMol and lastly docking was done by Auto dock Vina. The results show Ketamine antidepressant drug to be dominant over the other featured drug which included Alzheimer drugs and other antidepressant drugs. As seen through the docking results. The antidepressant drug with the help of BDNF tends to decrease the deposition of Aß peptide by showing a higher binding affinity.
Page(s):
333-333
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords:
Lithium
,
Alzheimers Disease
,
Antidepressant drugs
,
Brainderived neurotrophic factor
References:
References are not available for this document.
Citations
Citations are not available for this document.