Synthesis, spectral characterization and biological activity of N-Substituted derivatives of Tetrahydrofuran-2-ylmethylamine. | [Pakistan Journal of Chemistry • 2014]

Author(s):

1. Aziz-ur-Rehman: Department of Chemistry, Government College University, Lahore-54000, Pakistan

2. S. Rasool: Department of Chemistry, Government College University, Lahore-54000, Pakistan

3. M. A. Abbasi: Department of Chemistry, Government College University, Lahore-54000, Pakistan

4. K. M. Khan: HEJ Research Institute of Chemistry, ICCBS, University of Karachi, Karachi, Pakistan

5. I. Ahmad: Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan

6. S. Afzal: Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan

Abstract:

Tetrahydrofuran-2-ylmethylamine ,(1) was subjected to condensation reaction with 4-chlorobenzenesulfonyl chloride ,(2) in a mild basic medium to synthesize N-,(tetrahydrofuran-2-ylmethyl)-4-chlorobenzenesulfonamide ,(3). A series of N-substituted derivatives, 5a-f, were synthesized by condensing alkyl/aralkyl halides, 4a-f, with 3 under polar aprotic conditions using sodium hydride activator. The spectral characterization of all the molecules included IR, 1H-NMR and EI-MS data. The biological activity evaluation rendered 5c as moderate inhibitor of all the bacterial strains.

Page(s): 62-66

DOI: DOI not available

Published: Journal: Pakistan Journal of Chemistry, Volume: 4, Issue: 2, Year: 2014

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