Author(s):
1. Amina Hussain:
Department of Environmental Sciences, Fatima Jinnah Women University, Rawalpindi, Pakistan
Abstract:
Multiple therapeutic hydrophobic drugs can be delivered simultaneously by inorganic, biocompatible iron core mesoporous silica shell nanoparticles. We synthesized superparamagnetic iron oxide nanocrystals encapsulated within mesostructured silica spheres through the sol-gel process. The dose of hydrophobic drugs Paclitaxel (PTX) and Camptothecin (CPT) loading and released on Fe3O @SiO2 core/shell nanoparticle detected by U.V-visible 4 spectrophotometry using a platform of nanoparticles (NPS). After being subjected to external heating, the drug release eficiency of paclitaxel (PTX) and camptothecin (CPT) Fe3O4@SiO2 core/shell nanoparticles is increased. Paclitaxel (PTX) and Camptothecin (CPT) Fe3O4@SiO2 core/shell nanoparticles did not heat the solution when an alternating magnetic field (AMF) was applied, and there was only mild drug leakage. When compared to Fe3O4@MSNs, the nanoparticles (PTX) and (CPT) Fe3O4@MSNs function as cancer-targeting mediators, increasing the killing of PANC-1 cancer cells. Human cancer cells were given these therapeutic anticancer water-insoluble drugs with nanoparticles, which is a valuable vehicle for drug delivery, and induced the inhibition of proliferation. Therefore, the goal of this study to emphasize Fe3O4@SiO2 core/shell potential as a superior candidate for hydrophobic drug delivery to the PANC-1 cancer cell.
Page(s):
77-88
DOI:
DOI not available
Published:
Journal: Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, Volume: 58, Issue: 1, Year: 2021
Keywords:
hydrophobic drugs
,
Nanoparticles
,
PANC1 cells
,
release
,
Mesoporous silica
,
loading
References:
References are not available for this document.
Citations
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