Thuja Occidentalis l. Expedites Functional Recovery after Sciatic Nerve Crush Injury in Mice | [Pakistan Journal of Medical and Health Sciences • 2022]

Author(s):

1. SANAM NAZ: Government College University,Faisalabad,Pakistan

2. TAHIR FAROOQ: Government College University,Faisalabad,Pakistan

3. ARRUJE HAMEED: Government College University,Faisalabad,Pakistan

4. HASEEB ANWAR: Government College University Faisalabad,Pakistan

5. RIZWAN ASLAM: University of Agriculture,Faisalabad,Pakistan

6. SHOAIB AHMAD MALIK: Government College University,Faisalabad,Pakistan

7. RABIA AKRAM: Government College University Faisalabad,Pakistan

8. FAIQA SAJID: Government College University Faisalabad,Pakistan

9. ZAKIA SAEED: Government College University Faisalabad,Pakistan

10. GHULAM HUSSAIN: Sargodha Medical College, University of Sargodha, Sargodha, Pakistan

Abstract:

This study was conducted to find the potential of Thuja occidentalis (crude powder) in promoting the rate of recovery following the sciatic nerve injury in a mouse model. Thuja occidentalis was administered orally at a dosage of 2g/kg body weight. The motor functional recovery was measured using muscle grip force, sciatic functional index (SFI), and muscle weight. While the hotplate test and formalin test were performed to measure the recovery of sensory functions. Other biochemical tests were performed to analyze oxidative stress. We noted an early recovery of motor functions in the treatment group as determined by SFI (P<0.001) and grip strength test (P=0.01). Additionally, the mass of Gastrocnemius (P=0.04) and the Tibialis anterior (P=0.008) muscle was also recovered in response to the treatment. Similarly, it significantly expedites the recovery of sensory function as checked by the hotplate test (P=0.005). Moreover, the reduced oxidant status (P=0.03) and elevated antioxidants capacity (P=0.005) were also found in the treatment group. Collectively, all of these findings highlight that the Thuja occidentalis possesses the potential to accelerate functional recovery. The enhanced antioxidant capacity and reduced oxidants status of the biological system appears the possible reason for this improved functional regain after the sciatic nerve crush.

Page(s): 396-400

DOI: 10.53350/pjmhs22163396

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 16, Issue: 3, Year: 2022

Keywords:

oxidative stress , Nerve Injury , Peripheral nervous system , sensorimotor functional regain , Thuja occidentalis

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