A modified equation for calculating low density lipoprotein cholesterol in Pakistani population | [Khyber Medical University Journal • 2023]

Author(s):

1. Amjad Nawaz: Directorate of Research, Shifa Tameer-e- Millat University, Pitras Bukhari Road, H- 8/4, Islamabad 44000, Pakistan

2. Madeeha Khan: Directorate of Research, Shifa Tameer-e- Millat University, Pitras Bukhari Road, H- 8/4, Islamabad 44000, Pakistan

3. Quratul Ain: Directorate of Research, Shifa Tameer-e- Millat University, Pitras Bukhari Road, H- 8/4, Islamabad 44000, Pakistan; Translational Genomics Laboratory, Department of Biosciences, COMSATS University, Islamabad 44000, Pakistan

4. Hijab Batool: Chemical Pathology, Chughtai Institute of Pathology, Lahore, Pakistan

5. Muhammad Dilawar Khan: Chemical Pathology, Chughtai Institute of Pathology, Lahore, Pakistan

6. Mohammad Iqbal Khan: Shifa Tameer-e-Millat University, Pitras Bukhari Road, H-8/4, Islamabad 44000, Pakistan; Department of Vascular Surgery, Shifa International Hospital Pitras Bukhari Road, H-8/4, Islamabad 44000, Pakistan

7. Fouzia Sadiq: Directorate of Research, Shifa Tameer-e- Millat University, Pitras Bukhari Road, H- 8/4, Islamabad 44000, Pakistan

Abstract:

OBJECTIVE: To derive an equation for accurate estimation of low-density lipoprotein cholesterol (LDL-C) in the Pakistani population. METHODS: A modified equation was derived on the dataset (n = 59,148) from the Pakistani population, comprising directly measured LDL-C (dLDL-C) and other lipids using a regression model. The equation was validated on an internal (n = 29,633) and external dataset (n = 385,434), and the results were compared with the standard equations being used in the Pakistani population: Friedewald and Teerakanchana equation. The concordance between the dLDL-C and calculated LDL-C (cLDL-C) was determined by median difference (MD) and the agreement between dLDL-C and cLDL-C was analyzed by Bland Altman graphics. RESULTS: The modified equation (M.Eq) displayed best correlation (r = 0.974) and MD of -0.07 mmol/L on the derivation dataset. Similarly, the equation provided the best correlation and least MD on the internal (r = 0.970, MD = 0.13) and external validation datasets (r = 0.953, MD = -0.02). The BlandAltman plot for the modified equation displayed the least bias in the derivation (0.0012 mmol/L), internal validation (-0.13 mmol/L), and external validation (0.02 mmol/L). CONCLUSION: The modified equation can be utilized for clinical settings in Pakistan that do not facilitate direct measurements of LDL-C.

Page(s): 223-228

DOI: 10.35845/kmuj.2023.23439

Published: Journal: Khyber Medical University Journal, Volume: 15, Issue: 4, Year: 2023

Keywords:

Cholesterol MeSH , Triglycerides MeSH , LDL MeSH , Lipoproteins , Teerakanchana NonMeSH , Friedewald NonMeSH , Modified equation NonMeSH , Analysis NonMeSH , Bland Altman NonMeSH , Cardiovascular Diseases MeSH

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views