A Pakistani sample population study of clinical associations with MR imaging patterns in cerebral palsy | [Pakistan Paediatric Journal • 2023]

Author(s):

1. SABA FATIMA: Department of Pediatric Radiology, UCHS and The Children’s Hospital, Lahore, Pakistan

2. HINA AZHAR: Department of Pediatrics Developmental UCHS and The Children’s Hospital, Lahore, Pakistan

3. AMBER GORAYA: Department of Pediatric Radiology, UCHS and The Children’s Hospital, Lahore, Pakistan

4. Ammara Hina: Department of Pediatrics Developmental UCHS and The Children’s Hospital, Lahore, Pakistan

5. Abid Ali Qureshi: Department of Pediatric Radiology, UCHS and The Children’s Hospital, Lahore, Pakistan

Abstract:

Objectives: To describe and analyze various MRI imaging patterns in children with clinical diagnosis of Cerebral Palsy according to multiple peri/post natal factors, clinical subtypes of CP as well as motor/intellectual impairments. Study Design: Cross sectional analytical study Place and Duration of Study: This study was conducted in Department of Developmental/Behavioral Pediatrics and Department of Pediatric Radiology, UCHS and The Children’s Hospital, Lahore over a duration of 3 months Material and Methods: 57 diagnosed patients of Cerebral Palsy were enrolled and assessed for various peri/post natal risk factors, types of CP and different impairments. MRI brain were performed and reported according to MRICS (MRI Classification System) by Pediatric Radiologists. Descriptive analysis was performed using SPSS 24. Results: 57.7% patients exhibited Predominant White Matter Injury (PWMI) while Predominant Gray Matter Injury (PGMI) was noted in 17.7% of patients. Quadriplegic CP was the most common subtype in this population found in 76.9% patients out of which 62.5% had PWMI on MRI brain followed by miscellaneous pattern. More than 50% of population suffered from birth asphyxia as natal risk factor and 32.7% patients suffered from neonatal infections as post natal risk factor with PWMI being the commonest MRICS pattern in both of these groups. Early motor and intellectual impairments were more common in this population with PWMI as commonest MRICS pattern. Conclusion: Standardized classification like MRICS of brain imaging findings can help in establishing the pathogenesis and various clinical manifestations of CP

Page(s): 301-307

DOI: DOI not available

Published: Journal: Pakistan Paediatric Journal, Volume: 47, Issue: 3, Year: 2023

Keywords:

Cerebral palsy , Birth asphyxia , Motor function , MRICS

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