The Predictive Value of the Inflammatory Markers P-selectin and Mcp1 in Determining the Length of Stay and 30-day Survival in the Differentiation of Sepsis Patients. | [Journal of Pakistan Medical Association • 2018]

Author(s):

1. Ali Duman: Department of Faculty of Medicine, Adnan Menderes Universtiy, Aydin

2. Kenan Ahmet Turkdogan: Department of Faculty of Medicine, Adnan Menderes Universtiy, Aydin

3. Mucahit Avcil: Department of Faculty of Medicine, Adnan Menderes Universtiy, Aydin

4. Cigdem Yenisey: Department of Biochemistry, Adnan Menderes Universtiy, Aydin

5. Mevlut Ture: Department of Biochemistry, Adnan Menderes Universtiy, Aydin, Turkey

6. Ayhan Akoz: Department of Biochemistry, Adnan Menderes Universtiy, Aydin

7. Bekir Dagli: Department of Emergency Medicine, Adnan Menderes Universtiy, Aydin

8. Mucahit Kapci: Department of Emergency Medicine, Adnan Menderes Universtiy, Aydin

9. Serhat Orun: Emergecy Service, Bandirma State Hospital, Balikesir, Turkey

Abstract:

Objectives: Sepsis is the leading disease that is diagnosed late and still has a mortal course in emergency departments. The primary factors that will reduce both morbidity and mortality are early diagnosis and an early treatment approach. Therefore, in this study, P-selectin and MCP1 levels, which are known to be markers of inflammation, were examined in patients being followed up in intensive care. Methods: Patients evaluated with a preliminary diagnosis of sepsis in the emergency intensive care unit between September 2015 and August 2016 were classified as having sepsis or infection according to the Q- SOFA criteria, and the P-selectin values were compared. Results: In the sepsis group, GCS was determined as 13 (12-13), SBP 90 (80-110), tachypnea 24 (22-26), lactate 3.8 (0.6-16.0), MAP 70 (60-77), and LOS 16 days (9.5-20.3). In the ROC analysis, the sensitivity of P-selectin and MCP1 in the differentiation of patients with and without sepsis was 95.7%, and 73.8%, and the specificity was 97.8% and 73.8%, respectively. According to the cutoff values, the sensitivity and specificity in the prediction of patient mortality were 71.4% and 65.6% in P-selectin and 78.6% and 65.6% in MCP1. Conclusion: The P-selectin and MCP1 values in the emergency department can differentiate sepsis patients according to the Q-SOFA criteria and showed 30-day mortality at a significant level. Therefore, in patients with suspected sepsis in an emergency department, MCP1 can be of benefit to physicians in their decisions regarding LOS and transfer to intensive care.

Page(s): 1321-1326

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 68, Issue: 9, Year: 2018

Keywords:

Keywords are not available for this article.

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